Young adults and metachronous neoplasia: risks for future advanced adenomas and large serrated polyps compared with older adults

Recent increases in colorectal cancer (CRC) incidence in adults less than 50 years of age have led to more colonoscopies in this age group. As a result, there may be an increasing number of adults1cm) serrated polyps in younger versus older adults who return for a follow-up colonoscopy.
Source: Gastrointestinal Endoscopy - Category: Gastroenterology Authors: Source Type: research

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Publication date: Available online 26 February 2020Source: Meta GeneAuthor(s): Salma Begum Bhyan, YongKiat Wee, Mingyu Luo, Yining Liu, Min Zhao
Source: Meta Gene - Category: Genetics & Stem Cells Source Type: research
ConclusionNEAT1 upregulateIGF2 expression through absorbing miR ‐185‐5p to enhances the migration and invasion of colon cancer cells.
Source: Molecular Genetics & Genomic Medicine - Category: Genetics & Stem Cells Authors: Tags: ORIGINAL ARTICLE Source Type: research
ConclusionOur results suggest that the combination of altered expression of genes involved in signaling pathways of immune response and apoptosis control may contribute directly to the main characteristics observed in BS, such as recurrent infections, growth failure, and high risk of cancer. Transcriptome studies of other instability syndromes could allow a more accurate analysis of the relevant gene interactions associated with the destabilization of the genome. This is a first description of the profile of differential gene expression related to immunological aspects detected in patients with BS by RNA ‐seq.
Source: Molecular Genetics & Genomic Medicine - Category: Genetics & Stem Cells Authors: Tags: CLINICAL REPORT Source Type: research
Helicobacter pylori is one of the most prevalent infection worldwide. It affects individuals of different age groups. Aging ‐associated risk factors should be considered. Future studies, related to aging andH. pylori infection with extragastric disease can help to provide vivid evidences. AbstractHelicobacter pylori is one of the most prevalent infection worldwide. It affects individuals of different age groups. Elderly people tend to resist eradication treatment and worsening of infection can lead to several gastric and non ‐gastric pathologies. Aging‐associated cellular and molecular alteration can increase the ris...
Source: Molecular Genetics & Genomic Medicine - Category: Genetics & Stem Cells Authors: Tags: REVIEW ARTICLE Source Type: research
ConclusionsHigh-risk advanced adenomas are predominantly left sided. This focuses attention on the rectum and left colon where carcinogenesis is strong in the young.
Source: International Journal of Colorectal Disease - Category: Gastroenterology Source Type: research
Authors: Colace L, Boccia S, De Maria R, Zeuner A Abstract Colorectal cancer (CRC) holds the woeful record of being the most preventable but least prevented type of cancer. Although healthy lifestyles and screening programs associated to early polyp removal greatly reduce CRC incidence and CRC-related death, the overall lack of information and of effective preventive policies is promoting an overwhelming global escalation of this disease. Moreover, new challenges such as the increasing occurrence of aggressive CRC in young adults highlight underlying changes not only in the incidence but also in the nature of this ...
Source: Ecancermedicalscience - Category: Cancer & Oncology Tags: Ecancermedicalscience Source Type: research
Abstract Background and AimsThe incidence and disease burden of colorectal cancer (CRC) in young adults were increasing. However, there was a dearth of advice on how to identify young population at risk for neoplastic colonic polyps (NCPs) and CRC. We aimed to indentify risk factors for NCPs and CRC in young adults presenting with bloody stool. Methods1,496 subjects younger than 40‐year‐old who underwent colonoscopy due to bloody stool from 2005 to 2014 were enrolled in this retrospective study as the study group, and 1481 age and gender matched asymptomatic subjects who underwent colonoscopy for health checkup from 20...
Source: Journal of Gastroenterology and Hepatology - Category: Gastroenterology Authors: Tags: Gastroenterology Source Type: research
The Growing Toll of Our Ever-Expanding WaistlinesBy  JANE E. BRODY NOV. 13, 2017Paul Rogers I hope you ’re not chomping on a bagel or, worse, a doughnut while you read about what is probably the most serious public health irony of the last half century in this country: As one major killer — smoking — declined, another rose precipitously to take its place: obesity.Many cancer deaths were averted after millions quit lighting up, but they are now rising because even greater numbers are unable to keep their waistlines in check.Today, obesity and smoking remain the two leading causes of pre...
Source: Dr Portnay - Category: Cardiology Authors: Source Type: blogs
We describe the polyp characteristics on baseline and follow-up colonoscopy in adults  
Source: Gastrointestinal Endoscopy - Category: Gastroenterology Authors: Tags: Original article Source Type: research
We describe the polyp characteristics on baseline and follow-up colonoscopy in adults
Source: Gastrointestinal Endoscopy - Category: Gastroenterology Authors: Source Type: research
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