Please check the hierarchy of the section headings.Paediatric Oncology System Integration Tool (POSIT) for the Joint Analysis of the Performance of Childhood Cancer Programs and Health Systems

Publication date: Available online 21 November 2019Source: Journal of Cancer PolicyAuthor(s): Brandon Maser, Lisa M. Force, Paola Friedrich, Federico Antillon, Ramandeep S. Arora, Cristian A. Herrera, Carlos Rodriguez-Galindo, Rifat Atun, Avram DenburgAbstractTo help understand how health systems and sociopolitical contexts intersect with and impact the performance of childhood cancer care in low- and middle-income countries (LMICs), we have developed a systems-level framework for analyzing the performance of LMIC childhood cancer programs within their health system contexts: The Paediatric Oncology System Integration Tool (POSIT). POSIT development was informed by consultation with experts in global paediatric oncology, a literature review of childhood cancer performance assessment in LMICs, and a review of general health system literature. Review results were thematically analyzed and conceptually integrated with results from expert consultation to produce our final framework. Our findings from the childhood cancer performance literature demonstrate a current gap in efforts to strengthen the performance of childhood cancer at a health systems-level in LMICs. The POSIT framework incorporates important system-level determinants of childhood cancer performance and synthesizes these with general health system concepts. It outlines the key functional domains of childhood cancer systems – governance, financing, health workforce, infrastructure, health information systems, m...
Source: Journal of Cancer Policy - Category: Cancer & Oncology Source Type: research

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Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Publication date: March 2020Source: Journal of Cancer Policy, Volume 23Author(s): Brandon Maser, Lisa M. Force, Paola Friedrich, Federico Antillon, Ramandeep S. Arora, Cristian A. Herrera, Carlos Rodriguez-Galindo, Rifat Atun, Avram DenburgAbstractTo help understand how health systems and sociopolitical contexts intersect with and impact the performance of childhood cancer care in low- and middle-income countries (LMICs), we have developed a systems-level framework for analyzing the performance of LMIC childhood cancer programs within their health system contexts: The Paediatric Oncology System Integration Tool (POSIT). PO...
Source: Journal of Cancer Policy - Category: Cancer & Oncology Source Type: research
This article reviews the current landscape of antibody-based and cellular immunotherapies under current clinical evaluation with an emphasis on active or soon-to-open phase 1 trials for children with relapsed/refractory AML. PMID: 31808843 [PubMed - in process]
Source: Hematology ASH Education Program - Category: Hematology Tags: Hematology Am Soc Hematol Educ Program Source Type: research
Authors: Petropoulos AC, Moschovi M Abstract Late cardiotoxicity following treatment of malignancy diseases has been long established. Cancer therapeutics-related cardiac dysfunction (CTRCD), acute arrhythmias, pericardial disease, valvopathies and early atherosclerotic Cardiovascular Disease (CVD), are the clinical presentations of cardiotoxicity. Although these clinical modalities can affect adults treated for malignancies, they are more common to present in the pediatric survivors as improvement of prognosis, nowadays exists. Studies have shown that CVD can present earlier than thirty years, post treatment. If a...
Source: Hellenic Journal of Nuclear Medicine - Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research
The objective of the current study was to determine if the development of thyroid cancer is associated with a differential survival in radiation-exposed individuals. METHODS: We conducted a matched prospective cohort mortality follow-up study based on data from a cohort of 4296 individuals who were irradiated for enlarged tonsils during their childhood (between 1939 and 1962) and were prospectively followed since 1974. The study matched an irradiated subject who developed (was exposed to) thyroid cancer (a "case") and two irradiated subjects, who had not developed (were not exposed to) thyroid cancer ("c...
Source: Thyroid : official journal of the American Thyroid Association - Category: Endocrinology Tags: Thyroid Source Type: research
Despite advances in the field of pediatric oncology, cancer remains a leading cause of death in children. The delays in cancer diagnosis may occur throughout the diagnostic pathway. Diagnosis of childhood canc...
Source: BMC Pediatrics - Category: Pediatrics Authors: Tags: Research article Source Type: research
AbstractThe capacity of single-agent therapy with immune checkpoint inhibitors to control solid cancers by unleashing preexisting local antitumor T cell responses has renewed interest in the broader use of T cells as anticancer therapeutics. At the same time, durable responses of refractory B-lineage malignancies to chimeric-receptor engineered T cells illustrate that T cells can be effectively redirected to cancers that lack preexisting tumor antigen-specific T cells, as most typical childhood cancers. This review summarizes strategies by which T cells can be modified to recognize defined antigens, with a focus on chimeri...
Source: Cancer and Metastasis Reviews - Category: Cancer & Oncology Source Type: research
This study uses cross-sectional, descriptive-analytical methodology to explore how Twitter was employed during CCAM. We collected childhood cancer-related tweets from August 30 to October 2, 2015, which coincided with CCAM and several days before and after the awareness month. Using MALLET, we applied Latent Dirichlet allocation statistical modeling to extract the main topics of the collected tweets. We then explored how four different types of accounts —organizations, news agencies, celebrities, and individuals—used social media to talk about childhood cancer during CCAM using qualitative content analysis. Our...
Source: Network Modeling Analysis in Health Informatics and Bioinformatics - Category: Bioinformatics Source Type: research
(Wellcome Trust Sanger Institute) A fundamental change in our understanding of the childhood kidney cancer Wilms' tumor is on the horizon, after the discovery of its earliest genetic root by scientists at the Wellcome Sanger Institute and their collaborators. By comparing genome sequences from normal kidney tissue and tumors, the team identified patches of normal-looking kidney tissue that in fact carried DNA changes that cause Wilms' tumor.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news
Adult cancers often arise from premalignant clonal expansions. Whether the same is true of childhood tumors has been unclear. To investigate whether Wilms tumor (nephroblastoma; a childhood kidney cancer) develops from a premalignant background, we examined the phylogenetic relationship between tumors and corresponding normal tissues. In 14 of 23 cases studied (61%), we found premalignant clonal expansions in morphologically normal kidney tissues that preceded tumor development. These clonal expansions were defined by somatic mutations shared between tumor and normal tissues but absent from blood cells. We also found hyper...
Source: ScienceNOW - Category: Science Authors: Tags: Development, Medicine, Diseases reports Source Type: news
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