Genetic and metagenomics determinants of Fatty Liver Disease ad Obesity in children and adolescents

Date: Friday, 11 22, 2019; Speaker: Nicola Santoro, MD, PhD, Assistant Professor of Pediatrics (Endocrinology), Yale School of Medicine; Building 10 CRC; FAES 1&2
Source: NIH Calendar of Events - Category: American Health Source Type: events

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ConclusionsChildren with obesity and increased liver transaminases as surrogates of NAFLD should be screened for T2DM.
Source: Pediatric Obesity - Category: Eating Disorders & Weight Management Authors: Tags: ORIGINAL RESEARCH Source Type: research
DiscussionThis overview will assess current evidence from systematic reviews for the association between cadmium exposure and risk of T2DM and other metabolic morbidities. This overview may be helpful for policy-makers and healthcare teams aiming to mitigate T2DM risk in populations at risk of cadmium exposure.Systematic review registrationPROSPERO CRD42019125956
Source: Systematic Reviews - Category: International Medicine & Public Health Source Type: research
Scientists from 22 institutions, including UCLA, are recommending early diagnosis, prevention and treatment of severe chronic inflammation to reduce the risk of chronic disease and death worldwide.The group of international experts, which also includes scientists from the National Institutes of Health, Stanford University, Harvard Medical School, Columbia University Medical Center and University College London, point to inflammation-related diseases as the cause of 50 percent of all deaths worldwide.Inflammation is a naturally occurring response by the body ’s immune system that helps fight illness and infection. Whe...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news
Non-alcoholic fatty liver disease (NAFLD) is characterized by triglyceride accumulation in the hepatocytes in the absence of alcohol overconsumption, commonly associated with insulin resistance and obesity. Bo...
Source: Journal of Translational Medicine - Category: Research Authors: Tags: Protocol Source Type: research
AbstractThe term nonalcoholic fatty liver disease (NAFLD) comprises a spectrum of increasingly harmful conditions ranging from nonalcoholic fatty liver (NAFL) to nonalcoholic steatohepatitis (NASH) to liver fibrosis and end-stage cirrhosis. NAFLD is the currently most common form of chronic liver disease in both adults and children worldwide. As NAFLD evolves as a global pandemic alongside the still growing prevalence of metabolic syndrome, obesity, and diabetes, it is inevitable to develop effective counterstrategies. Over the last decades, great effort has been dedicated to the understanding of the pathogenesis of NAFLD....
Source: Hepatology International - Category: Infectious Diseases Source Type: research
Laparra JM Abstract Non-alcoholic fatty liver disease (NAFLD) is indisputably the most widespread liver disease worldwide, leading to a significant increase in patient morbidity, mortality, and health care utilization. The gut microbiota and its genome (microbiome) have emerged as a novel modulator of the immunometabolic processes that NAFLD implies, but microbiota-targeted interventions have resulted both astounding and at the same time unsuccessful. The most relevant alteration appears to be the overgrowth of Gram-negative bacteria, characterized by an increased ratio of Firmicutes to Bacteroidetes, although cu...
Source: Nutricion Hospitalaria - Category: Nutrition Authors: Tags: Nutr Hosp Source Type: research
We are grateful to the editor for the opportunity to disseminate our findings in our work entitled: Impact of a preoperative low-calorie diet on liver histology in patients with fatty liver disease undergoing bariatric surgery1. And, to Dr. Ann Rogers for her accompanying commentary providing her valuable insight regarding nonalcoholic fatty liver disease (NAFLD) and its high prevalence in bariatric patients.2
Source: Surgery for Obesity and Related Diseases - Category: Surgery Authors: Tags: Letter to the Editor Source Type: research
Conditions:   Non-Alcoholic Fatty Liver Disease;   Non-Alcoholic Steatohepatitis;   Obesity;   Diabetes Mellitus, Type 2 Intervention:   Device: Spartz Balloon Sponsor:   Asian Institute of Gastroenterology, India Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Obesity is associated with nonalcoholic fatty liver disease which is one of the most common causes of chronic liver disease. FibroScan is a noninvasive tool for liver stiffness measurement and controlled attenuation parameter to evaluate liver steatosis and fibrosis. We aimed to demonstrate the effect of laparoscopic sleeve gastrectomy on liver steatosis and fibrosis. Of the 120 consecutive patients screened, 72 were enrolled in this study. FibroScan M probe and XL probe were used for the evaluation of liver steatosis and fibrosis. Fifty-two patients (72.2%) were female individuals and 20 (27.8%) were male individuals; the...
Source: Surgical Laparoscopy, Endoscopy and Percutaneous Techniques - Category: Surgery Tags: Original Articles Source Type: research
ra Propolis is a natural product resulting from the mixing of bee secretions with botanical exudates. Since propolis is rich in flavonoids and cinnamic acid derivatives, the application of propolis extracts has been tried in therapies against cancer, inflammation, and metabolic diseases. As metabolic diseases develop relatively slowly in patients, the therapeutic effects of propolis in humans should be evaluated over long periods of time. Moreover, several factors such as medical history, genetic inheritance, and living environment should be taken into consideration in human studies. Animal models, especially mice and ...
Source: Molecules - Category: Chemistry Authors: Tags: Review Source Type: research
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