The impact of paternal alcohol consumption on offspring brain and behavioral development.

CONCLUSIONS: These results demonstrate that the developmental impact of preconception PatEE is more harmful than previously thought and provide additional insights into the biological mechanisms that may underlie atypical behavior observed in children of alcoholic fathers. PMID: 31746471 [PubMed - as supplied by publisher]
Source: Alcoholism, Clinical and Experimental Research - Category: Addiction Authors: Tags: Alcohol Clin Exp Res Source Type: research

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Manitoba's new FASD court is designed for people like Everett Redhead, who has some of the wide-ranging symptoms of fetal alcohol spectrum disorders. CBC News followed him from his first court date in April to sentencing.
Source: CBC | Health - Category: Consumer Health News Tags: News/Canada/Manitoba Source Type: news
Legal experts in Manitoba’s new court to help offenders with fetal alcohol spectrum disorder (FASD) say demand for the docket has skyrocketed since its launch, leading to long wait times and plans to expand.
Source: CBC | Health - Category: Consumer Health News Tags: News/Canada/Manitoba Source Type: news
Publication date: 10 February 2020Source: Neuroscience, Volume 427Author(s): Alessandro Ieraci, Daniel G. HerreraAbstractDrinking alcohol during pregnancy is particularly detrimental for the developing brain and may cause a broad spectrum of cognitive and behavioral impairments, collectively known as fetal alcohol spectrum disorder (FASD). While behavioral abnormalities and brain damage have been widely investigated in animal models of FASD, the sex differences in the vulnerability to perinatal ethanol exposure have received less consideration. Here we investigated the long-term behavioral and molecular effects of acute et...
Source: Neuroscience - Category: Neuroscience Source Type: research
We examined age-related differences in the volume of the corpus callosum, basal ganglia, and cerebellum across adolescence and young adulthood, due to the sensitivity of these regions to prenatal alcohol exposure. T1-weighted anatomical magnetic resonance images (MRI) were acquired from a cross-sectional sample of subjects 13-30 years old who had received an alcohol-related diagnosis (FASD, n=107) and typically developing controls (CON, n=56). FreeSurfer v5.3 was used to obtain volumetric data for the corpus callosum, caudate, putamen, pallidum, and cerebellum. Analysis of variance (ANOVA) was used to examine the effects o...
Source: Brain Research - Category: Neurology Authors: Tags: Brain Res Source Type: research
To investigate whether ophthalmological findings in children with fetal alcohol spectrum disorders (FASD) persist into young adulthood.
Source: American Journal of Ophthalmology - Category: Opthalmology Authors: Tags: Original Articles Source Type: research
BACKGROUND: Binge drinking (BD) is a serious risk factor for fetal alcohol spectrum disorders (FASD) and associated with more severe forms of the disorder. Thus, special attention to specific risk factors for BD adjacent to and during pregnancy is warrante...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
Publication date: Available online 7 January 2020Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Amanda Facciol, Celine Bailleul, Samuel Nguyen, Robert GerlaiAbstractFASD results from the developing fetus being exposed to alcohol, and is characterized by morphological, behavioural and cognitive deficits. However, the expression, severity and age of onset of these symptoms has been found to show variation. This variation may partly be due to the developmental stage at which alcohol reached the developing fetus. Previously, alcohol was shown to lead to significant concentration dependent beha...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - Category: Psychiatry Source Type: research
Abstract Fetal alcohol spectrum disorder (FASD), which is caused by prenatal alcohol exposure, can result in cell death in specific brain regions. Alcohol-induced neurocognitive defects offspring's are included with activation of oxidative-inflammatory cascade followed with wide apoptotic neurodegeneration in many brain's regions such as hippocampus. According to the latest studies, H2S (hydrogen sulfide) can protect neuronal cells via antioxidant, anti-inflammatory, and anti-apoptotic mechanisms in different animal models. Therefore, we aimed to evaluate the protective effects of H2S on ethanol-induced neuroinfla...
Source: Cell Research - Category: Cytology Authors: Tags: Neurotox Res Source Type: research
Purpose of review To highlight research, publications, and medical advancements in fetal alcohol spectrum disorder (FASD) over the past 18 months. Recent findings Prevalence numbers have been updated, allowing for a more accurate account of the societal impact. Further work on diagnostic techniques and the underlying mechanisms will allow us to better understand the pathophysiology of FASD and could translate into treatments for the condition. Continued research on new treatments and interventions is needed to improve the affected individual's health care and quality of life. Measurable outcomes allow us to tangibly m...
Source: Current Opinion in Endocrinology, Diabetes and Obesity - Category: Endocrinology Tags: GROWTH AND DEVELOPMENT: Lynne L. Levitsky Source Type: research
CONCLUSIONS: Maternal ACEs were common in this middle to upper-middle income, well-educated sample and impacted the next generation through BD in pregnancy. These findings combine with others to speak to the public health significance of maternal ACEs on alcohol-related behaviour among expectant mothers across the socioeconomic spectrum, and the need for targeted evidence-based interventions for this population. PMID: 31896532 [PubMed - as supplied by publisher]
Source: Child Abuse and Neglect - Category: Child Development Authors: Tags: Child Abuse Negl Source Type: research
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