Aprinoia starts study on PET tracer for Alzheimer's

Neuroscience biopharmaceutical company Aprinoia Therapeutics has announced...Read more on AuntMinnie.comRelated Reading: fMRI shows dementia patients' brain response to music New Alzheimer's definition relies on imaging biomarkers DTI-MRI ties lack of fitness to cognitive decline Flortaucipir-PET could lead in early Alzheimer's detection PET study links menopausal status to Alzheimer's
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news

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Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
This study is the first to provide a direct link between this inflammation and plaque development - by way of IFITM3. Scientists know that the production of IFITM3 starts in response to activation of the immune system by invading viruses and bacteria. These observations, combined with the new findings that IFITM3 directly contributes to plaque formation, suggest that viral and bacterial infections could increase the risk of Alzheimer's disease development. Indeed, researchers found that the level of IFITM3 in human brain samples correlated with levels of certain viral infections as well as with gamma-secretase activ...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
(IOS Press) Amsterdam, September 1, 2020-Alzheimer's disease (AD) is the most common neurodegenerative disease and the leading cause of dementia. It affects more women than men. A new study published in the Journal of Alzheimer's Disease indicates that factors such as age, reproductive stage, hormone levels, and the interplay with other risk factors should be considered in women and proposes a role for early menopausal estrogen replacement to protect against the development of AD.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
In this study, we sought to elucidate the role of VRK-1 in regulation of adult life span in C. elegans. We found that overexpression of VRK-1::GFP (green fluorescent protein), which was detected in the nuclei of cells in multiple somatic tissues, including the intestine, increased life span. Conversely, genetic inhibition of vrk-1 decreased life span. We further showed that vrk-1 was essential for the increased life span of mitochondrial respiratory mutants. We demonstrated that VRK-1 was responsible for increasing the level of active and phosphorylated form of AMPK, thus promoting longevity. A Fisetin Variant, C...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Abstract Menopause, an inevitable event in a woman's life, significantly increases risk of bone resorption and diseases such as Alzheimer's, vascular dementia, cardiac arrest, and stroke. The sole role of bones, as traditionally regarded, is to provide structural support for skeletal muscles and allow for ambulation, however this concept is becoming quickly outdated. New literature has emerged that suggests the bone cell-derived hormone osteocalcin (OCN) plays a pivotal role in cognition. OCN levels are correlated with bone mass density and bone turnover, and thus are strongly influenced by the changes associated ...
Source: Frontiers in Neuroendocrinology - Category: Endocrinology Authors: Tags: Front Neuroendocrinol Source Type: research
MRI scans show that accumulated iron in the outer layer of the brain is linked...Read more on AuntMinnie.comRelated Reading: fMRI shows dementia patients' brain response to music New Alzheimer's definition relies on imaging biomarkers DTI-MRI ties lack of fitness to cognitive decline Flortaucipir-PET could lead in early Alzheimer's detection PET study links menopausal status to Alzheimer's
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
DISCUSSION: These results may explain why women have higher dementia incidence compared to men after age 85, the age with the highest number of dementia cases. PMID: 32573980 [PubMed - as supplied by publisher]
Source: The Journal of Alzheimers Association - Category: Psychiatry Tags: Alzheimers Dement Source Type: research
A new PET technique can visualize early Alzheimer's disease by imaging the...Read more on AuntMinnie.comRelated Reading: fMRI shows dementia patients' brain response to music New Alzheimer's definition relies on imaging biomarkers Flortaucipir-PET could lead in early Alzheimer's detection PET study links menopausal status to Alzheimer's FDG-PET links physical activity to healthy brains
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
AbstractEstrogens play a crucial physiological function in the brain; however, debates exist concerning the role of estrogens in Alzheimer ’s disease (AD). Women during pre-, peri-, or menopause periods are more susceptible for developing AD, suggesting the connection of sex factors and a decreased estrogen signaling in AD pathogenesis. Yet, the underlying mechanism of estrogen-mediated neuroprotection is unclarified and is complicat ed by the existence of estrogen-related factors. Consequently, a deeper analysis of estrogen receptor (ER) expression and estrogen-metabolizing enzymes could interpret the importance of ...
Source: Molecular Neurobiology - Category: Neurology Source Type: research
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