Highlighting a Potential Pitfall: Positive: Treponema pallidum: Immunohistochemical Stain in a Patient Without Syphilis
We present a case of a man with genital condyloma acuminatum with a positive T. pallidum IHC stain but negative T. pallidum serologies and no syphilitic symptoms. It has been shown that the T. pallidum antibody IHC can cross-react, staining other spirochetes, including Borrelia burgdorferi and the Brachyspira family of intestinal spirochetes. Because of the proximity of our patient's lesions to the anus, and the persistently negative T. pallidum serologies, we believe nontreponemal spirochetes colonized the condyloma, giving a false-positive T. pallidum IHC. This cross-reactivity is a potential diagnostic pitfall and is important for the dermatopathologist to recognize, thereby avoiding false diagnosis of syphilis.
Conclusions: A significant increase (P = .02) in Lyme arthritis cases was observed at Oishei Children's Hospital of Buffalo. Lyme arthritis may clinically present similarly to other forms of arthritis, such as oligoarticular juvenile idiopathic arthritis, so health care providers should be aware of distinguishing clinical features, which include rapid onset of swelling and patient age. Because the geographic area of endemic Lyme disease is expanding, all health care providers need to be aware of Lyme arthritis as a possible diagnosis. PMID: 31819695 [PubMed]
Extending human papillomavirus (HPV) vaccination to middle-aged adults would be costly and likely yield only small added health benefits, according to a health economic model.Reuters Health Information
Vector-Borne and Zoonotic Diseases, Ahead of Print.
Insurance claim lines related to Lyme disease, a bacterial infection transmitted through the bite of black-legged ticks, increased by 117 percent across the country between 2007 and 2018, according to new research.
NEW YORK (CBS) – The United States has seen a big rise in the number of Lyme disease cases. A new study finds that the number of Americans diagnosed with the illness more than doubled over the past decade. Researchers at FAIR looked at private health insurance claims from 2007 to 2018. They found the biggest increase was in urban areas where claims for Lyme disease increased by more than 120%. Read The Report (PDF) “Lyme disease is the nation’s predominant tick-borne disease, and it is growing,” FAIR said in its report. Massachusetts was among the Top 10 states with the highest percentages of insura...
(FAIR Health) From 2007 to 2018, claim lines with diagnoses of Lyme disease increased nationally 117%. The new FAIR Health Study Uncovers Geographic, Age and Gender Variation, among Other Notable Statistics. Comparing Lyme disease to other tick-borne diseases, the study draws on data from FAIR Health's comprehensive repository of over 29 billion private healthcare claim records -- the largest in the country.
Conclusion: The current HPV vaccination program is predicted to be cost saving. Extending vaccination to older ages is predicted to produce small additional health benefits and result in substantially higher incremental cost-effectiveness ratios than the current recommendation. Primary Funding Source: Centers for Disease Control and Prevention. PMID: 31816629 [PubMed - as supplied by publisher]
MONDAY, Dec. 9, 2019 -- Extending the current human papillomavirus (HPV) vaccination program to age 45 years is expected to produce small additional reductions in HPV-associated diseases with high additional costs, according to a study published...
(American College of Physicians) A health economic model suggests that extending the US human papillomavirus (HPV) vaccination program to include women and men through age 45 would produce relatively small health benefits compared with the current immunization program. Findings from a modeling study are published in Annals of Internal Medicine.
In the original publication of this article  there was an error in the results section of the article.