Highlighting a Potential Pitfall: Positive: Treponema pallidum: Immunohistochemical Stain in a Patient Without Syphilis

We present a case of a man with genital condyloma acuminatum with a positive T. pallidum IHC stain but negative T. pallidum serologies and no syphilitic symptoms. It has been shown that the T. pallidum antibody IHC can cross-react, staining other spirochetes, including Borrelia burgdorferi and the Brachyspira family of intestinal spirochetes. Because of the proximity of our patient's lesions to the anus, and the persistently negative T. pallidum serologies, we believe nontreponemal spirochetes colonized the condyloma, giving a false-positive T. pallidum IHC. This cross-reactivity is a potential diagnostic pitfall and is important for the dermatopathologist to recognize, thereby avoiding false diagnosis of syphilis.
Source: The American Journal of Dermatopathology - Category: Pathology Tags: Brief Report Source Type: research

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Conclusions: A significant increase (P = .02) in Lyme arthritis cases was observed at Oishei Children's Hospital of Buffalo. Lyme arthritis may clinically present similarly to other forms of arthritis, such as oligoarticular juvenile idiopathic arthritis, so health care providers should be aware of distinguishing clinical features, which include rapid onset of swelling and patient age. Because the geographic area of endemic Lyme disease is expanding, all health care providers need to be aware of Lyme arthritis as a possible diagnosis. PMID: 31819695 [PubMed]
Source: Clinical Medicine Insights: Arthritis and Musculoskeletal Disorders - Category: Orthopaedics Tags: Clin Med Insights Arthritis Musculoskelet Disord Source Type: research
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Vector-Borne and Zoonotic Diseases, Ahead of Print.
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Insurance claim lines related to Lyme disease, a bacterial infection transmitted through the bite of black-legged ticks, increased by 117 percent across the country between 2007 and 2018, according to new research.
Source: Health News - UPI.com - Category: Consumer Health News Source Type: news
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Source: EurekAlert! - Infectious and Emerging Diseases - Category: Infectious Diseases Source Type: news
Conclusion: The current HPV vaccination program is predicted to be cost saving. Extending vaccination to older ages is predicted to produce small additional health benefits and result in substantially higher incremental cost-effectiveness ratios than the current recommendation. Primary Funding Source: Centers for Disease Control and Prevention. PMID: 31816629 [PubMed - as supplied by publisher]
Source: Annals of Internal Medicine - Category: Internal Medicine Authors: Tags: Ann Intern Med Source Type: research
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Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
(American College of Physicians) A health economic model suggests that extending the US human papillomavirus (HPV) vaccination program to include women and men through age 45 would produce relatively small health benefits compared with the current immunization program. Findings from a modeling study are published in Annals of Internal Medicine.
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