This Month in AJP

The role of Kv11.1 potassium channels in the lung is unclear. Shults et al (Am J Pathol, AJPA_2019_212) studied the expression of Kv11.1 in healthy human and rat lung tissues and in humans with chronic obstructive pulmonary disease (COPD)-associated pulmonary hypertension (PH) and rats with pulmonary arterial hypertension (PAH). Kv11.1 channels are amply expressed in and confined to the large pulmonary arteries (PAs) of healthy lung tissues. This expression increases in human lungs affected by COPD-associated PH and in mouse lungs with PAH, with detectable expression in small PAs.
Source: American Journal of Pathology - Category: Pathology Authors: Tags: This Month in AJP Source Type: research