Glucagon Like Peptide-1 Receptor Agonism Improves Nephrotoxic Serum Nephritis by Inhibiting T Cell Proliferation

Glucagon like peptide (GLP)-1 analogs such as liraglutide improved albuminuria in patients with type 2 diabetes in large randomized controlled trials. One of the suspected mechanisms is the anti-inflammatory potential of GLP-1 receptor (Glp1r) agonism. Thus, we tested the anti-inflammatory action of Glp1r-agonism in a non-diabetic, T-cell –mediated murine model of nephrotoxic serum nephritis (NTS). The role of Glp1r in NTS was evaluated by using Glp1r −/− mice or C57BL/6 mice treated with liraglutide.

Source: American Journal of Pathology - November 20, 2019 Category: Pathology Authors: Foteini Moschovaki Filippidou, Alexander H. Kirsch, Matthias Thelen, M áté Kétszeri, Katharina Artinger, Ida Aringer, Corinna Schabhüttl, Agnes A. Mooslechner, Bianca Frauscher, Marion Pollheimer, Tobias Niedrist, Andreas Meinitzer, Daniel J. Drucker, Source Type: research