Unaffected bone mineral density in Danish children and adolescents with type 1 diabetes
AbstractAimsAdults with type 1 diabetes mellitus (T1D) have decreased bone mineral density (BMD). Our study aimed at determining BMD and the association to metabolic control in children and adolescents with T1D.Methods244 patients (113 girls) with a median age of 14.3 years and T1D duration of 1–16 years were included. A dual-energy X-ray absorptiometry scan assessed BMDZ-scores excluding the head (total body less head, TBLH). TBLH-BMD were then investigated for associations to diabetes relevant variables such as HbA1c, insulin treatment, anthropometry and physical activity.ResultsIn all participants the TBLH-BMDZ-score (0.22 ± 0.96) was significantly higher than the references. Separated by sex, TBLH-BMDZ-score in boys (0.11 ± 0.84) was no different from healthy peers whereas TBLH-BMDZ-score was significantly higher in girls (0.36 ± 1.09). The higher TBLH-BMDZ-score in girls were explained by higher BMIZ-scores. Participants with assumed final height (based on age) had an average TBLH-BMDZ-score of 0.78 ± 1.06, significantly higher than references independent of gender, HbA1c, height- and weightZ-scores. Multiple regression analyses showed that TBLH BMDZ-score associated negatively to HbA1c (P = 0.003), pump treatment (P = 0.019) and screen-time (P = 0.005) and positively to weightZ-score (P
CONCLUSIONS: The mechanism underlying this phenomenon relates to a decrease in the inflammatory reaction and oxidative stress, as well as a decrease in leaky gut. Such reactions increase insulin sensitivity and reduce autoimmune responses. PMID: 32096204 [PubMed - in process]
This study is based on the German Disease Analyzer database and included 4258 adult individuals with a T1DM diagnosis documented between January 2000 and December 2015 in 1203 general practices in Germany. Individual matching of T1DM and non-diabetic patients was performed. The cumulative incidence of new fractures was shown for up to 10 years after the index date using Kaplan-Meier curves. Cox proportional hazard models (dependent variable: incident fracture) were used to estimate the effect of T1DM on fracture incidence, as well as the effect of predefined variables on fracture incidence.ResultsAfter 10 years...
ConclusionThere was a negative correlation between cost of care and glycemic control. Lower cost of care was associated with high burden of psychosocial illness and poor quality of life.
Conclusion: Changes in the choroid may occur before the development of diabetic retinopathy and seem to progress with increasing diabetes mellitus duration despite the absence of diabetic retinopathy and without associated retina thickening. Choroidal thickness could be valuable for screening in diabetic children.
Publication date: Available online 21 February 2020Source: Life SciencesAuthor(s): Yu-pu Liu, Shui-jin Shao, Hai-dong GuoAbstractDiabetic peripheral neuropathy (DPN) is a common complication of diabetes mellitus that affects approximately half of patients with diabetes. Current treatment regimens cannot treat DPN effectively. Schwann cells (SCs) are very sensitive to glucose concentration and insulin, and closely associated with the occurrence and development of type 1 diabetic mellitus (T1DM) and DPN. Apoptosis of SCs is induced by hyperglycemia and is involved in the pathogenesis of DPN. This review considers the patholo...
Conditions: Type 1 Diabetes; Pregnancy in Diabetic Intervention: Sponsors: Ana Braescu; University of Arizona Terminated
Insulin allergy brought out 8 years after starting insulin therapy in a subject with type 1 diabetes mellitus. Acta Diabetol. 2020 Feb 20;: Authors: Kimura T, Fushimi Y, Hayashi H, Tatsumi F, Kanda-Kimura Y, Shimoda M, Hirukawa H, Sanada J, Obata A, Kohara K, Nakanishi S, Mune T, Kaku K, Kaneto H PMID: 32078040 [PubMed - as supplied by publisher]
Authors: Katsimardou A, Imprialos K, Stavropoulos K, Sachinidis A, Doumas M, Athyros VG Abstract Introduction: Type 1 diabetes mellitus (T1DM) is a chronic, autoimmune disease that is characterized by total absence of insulin production. Hypertension is a common comorbidity in T1DM with complex pathophysiology, while it is also a well-recognized risk factor for the development of cardiovascular disease (CVD), as well as other microvascular diabetic complications.Areas covered: The purpose of this review is to present the current definitions, epidemiological data and prevalence rates of hypertension in T1DM, as well...