Kidney function and its association to imminent, short- and long-term fracture risk —a longitudinal study in older women

ConclusionOlder women with mild-moderate reduction of kidney function are at increased risk of fractures, but not those with the worst function. Our findings furthermore confirm the value of osteoporosis assessment and it is possible that in this age group, age-related decline of kidney function has limited contribution compared with BMD.
Source: Osteoporosis International - Category: Orthopaedics Source Type: research

Related Links:

Conclusion A great deal of progress is being made in the matter of treating aging: in advocacy, in funding, in the research and development. It can never be enough, and it can never be fast enough, given the enormous cost in suffering and lost lives. The longevity industry is really only just getting started in the grand scheme of things: it looks vast to those of us who followed the slow, halting progress in aging research that was the state of things a decade or two ago. But it is still tiny compared to the rest of the medical industry, and it remains the case that there is a great deal of work yet to be done at all...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Conclusion A great deal of progress is being made in the matter of treating aging: in advocacy, in funding, in the research and development. It can never be enough, and it can never be fast enough, given the enormous cost in suffering and lost lives. The longevity industry is really only just getting started in the grand scheme of things: it looks vast to those of us who followed the slow, halting progress in aging research that was the state of things a decade or two ago. But it is still tiny compared to the rest of the medical industry, and it remains the case that there is a great deal of work yet to be done at all...
Source: Fight Aging! - Category: Research Authors: Tags: Of Interest Source Type: blogs
Mrs. D is an 89-year-old African American woman who has moved into the nursing home directly from her home. Her husband became ill and could no longer care for her. She has a history of heart failure and was seeing her cardiologist for weekly weights, but she stopped because she could no longer tolerate the outings. She has had multiple falls at home; most recently, she sustained a left wrist fracture. Her past medical history includes allergic rhinitis, arthritis, esophageal reflux, hyperlipidemia, hypertension, chronic kidney disease, a herniated cervical disc, osteoporosis, and situational depression.
Source: Caring for the Ages - Category: Health Management Authors: Tags: Interdisciplinary Team Case Studies Source Type: news
Publication date: November 2019Source: Advances in Chronic Kidney Disease, Volume 26, Issue 6Author(s): Pieter Evenepoel, Britt Opdebeeck, Karel David, Patrick C. D'HaesePatients with chronic kidney disease (CKD) are at increased risk of osteoporosis and vascular calcification. Bone demineralization and vascular mineralization go often hand in hand in CKD, similar to as in the general population. This contradictory association is independent of aging and is commonly referred to as the “calcification paradox” or the bone-vascular axis. Various common risk factors and mechanisms have been identified. Alternativel...
Source: Advances in Chronic Kidney Disease - Category: Urology & Nephrology Source Type: research
In conclusion, there are new well tolerated and effective K+-binding agents for acutely and chronically managing hyperkalemia.
Source: Current Opinion in Nephrology and Hypertension - Category: Urology & Nephrology Tags: NOVEL THERAPEUTIC APPROACHES IN NEPHROLOGY AND HYPERTENSION: Edited by Kamyar Kalantar-Zadeh and Ekamol Tantisattamo Source Type: research
In conclusion, our findings suggest that risedronate could maintain glomerular barrier function by rescuing Pi-induced podocyte injury. PMID: 31772574 [PubMed]
Source: International Journal of Endocrinology - Category: Endocrinology Tags: Int J Endocrinol Source Type: research
AbstractPurpose of ReviewTo summarize the literature regarding alterations in bone health in patients with glomerular kidney disease and highlight areas in need of additional investigation.Recent FindingsThere is mounting evidence that children and adults with glomerular conditions, with or without compromised kidney function, comprise a distinct subgroup of patients with unique risk factors for altered bone health.SummaryPatients with glomerular kidney disease are exposed to both disease-related and treatment-related factors that affect bone structure and function. In addition to chronic kidney disease –related risk...
Source: Current Osteoporosis Reports - Category: Orthopaedics Source Type: research
The objective of this systematic review and meta-analysis was to assess whether, and in which degree, CKD was associated with falls and fractures in adults. A systematic search in PubMed, Embase, CINAHL, and The Cochrane Library was performed on 7 September 2018. All retrospective, cross-sectional, and longitudinal studies of adults (18 years of older) that studied the association between CKD, fractures, and falls were included. Additional studies were identified by cross-referencing. A total of 39 publications were included, of which two publications assessed three types of outcome and four publications assessed two types...
Source: Osteoporosis International - Category: Orthopaedics Source Type: research
AbstractPurposeTo investigate changes in bone mineral density (BMD) following denosumab after previous bisphosphonate therapy and the impact of chronic kidney disease (CKD) on response.MethodsA retrospective study of 134 patients (11 M, 123 F) aged [mean (SD)] 72 [11] years on denosumab was undertaken. Ninety-five patients had previously been on oral and 28 on iv bisphosphonate. Lumbar spine (LS), total hip (TH) and femoral neck (FN) BMD were measured before treatment and at 2.7 [1.2] years. GFR was
Source: Journal of Endocrinological Investigation - Category: Endocrinology Source Type: research
ConclusionsWe found that among individuals with stage 3 and 4 CKD, PTH was an independent predictor of fractures, vascular events, and death. Additional epidemiologic studies are needed to confirm these findings. If a target PTH range can be confirmed, then randomized placebo-controlled trials will be needed to confirm that treating HPT reduces the risk of fracture, vascular events, and death.
Source: Osteoporosis International - Category: Orthopaedics Source Type: research
More News: Chronic Kidney Disease | Orthopaedics | Osteoporosis | Study | Urology & Nephrology | Women