Breast cancer prevention in high risk women

Publication date: Available online 21 November 2019Source: Best Practice &Research Clinical Obstetrics &GynaecologyAuthor(s): Mangesh A. Thorat, Rajeshkumar BalasubramanianAbstractWomen at a high-risk of developing breast cancer are a heterogenous group of women including those with and without high-risk germline mutation/s. Prevention in these women requires a personalised and multidisciplinary approach. Preventive therapy with Selective oestrogen receptor modulators (SERMs) like tamoxifen and aromatase inhibitors (AIs) substantially reduces breast cancer risk well beyond active treatment period. The importance of benign breast disease as a marker of increased breast cancer risk remains under-appreciated, and although the benefit of preventive therapy may be greater in such women, preventive therapy remains underutilised in these and other high-risk women. Bilateral Risk-Reducing Mastectomy reduces risk of developing breast cancer by 90% in high-risk women such as carriers of BRCA mutations. It also improves breast cancer specific survival in BRCA1 carriers. Bilateral Risk-Reducing Salpingo-Oophorectomy may also reduce risk in premenopausal BRCA2 carriers. Further research to improve risk models, to identify surrogate biomarkers of preventive therapy benefit and develop newer preventive agents is needed.
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - Category: OBGYN Source Type: research

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Publication date: Available online 20 January 2020Source: Pathology - Research and PracticeAuthor(s): In Hye Song, Sook-Hee Hong, Kyo Yeong Lee, Jun Kang, Sung Hak Lee, Jieun Lee, Ahwon LeeAbstractDevelopment of molecular technology has led to the expansion of next generation sequencing (NGS) in area of diagnostic pathology. Here we present a case in which a lung tumor, which resembled an atypical carcinoid tumor, was revealed as metastatic breast cancer by next generation sequencing. A 50-year-old female, who had received modified radical mastectomy for breast cancer, presented with a 2.1 cm sized lung mass. The ma...
Source: Pathology Research and Practice - Category: Pathology Source Type: research
Breast cancer is the most commonly diagnosed invasive cancer in women worldwide. The physical and psychological consequences of breast cancer can be somewhat mitigated with reconstruction, making it an integral part of the treatment approach in women requiring mastectomy.1 With improvements in surgical management, increasing amounts of the native breast skin can be spared with oncologic safety. This skin sparing approach has improved aesthetic outcomes, but it does not affect the loss of sensation in the breast, one of the most commonly reported deficiencies after mastectomy.
Source: Journal of Plastic, Reconstructive and Aesthetic Surgery - Category: Cosmetic Surgery Authors: Tags: Correspondence and Communications Source Type: research
ConclusionOverall, these guidelines provide consistent recommendations on who should receive breast reconstruction education, who is a candidate for postmastectomy breast reconstruction, and the appropriate timing of reconstruction and extent of mastectomy. Future updates from all should focus on expanding to include alloplastic and autologous forms of reconstruction and should include a broad scope of relevant questions.
Source: European Journal of Surgical Oncology (EJSO) - Category: Surgery Source Type: research
Conditions:   Breast Cancer;   Mastectomy; Lymphedema;   Pain, Shoulder;   Mobility Limitation Interventions:   Other: Myofascial Massage;   Other: Light Touch Sponsor:   MetroHealth Medical Center Not yet recruiting
Source: - Category: Research Source Type: clinical trials
AbstractPurposeAxillary treatment strategies for the young woman with early-stage, clinically node-negative breast cancer undergoing upfront surgery found to have 1 –3 positive sentinel lymph nodes (SLNs) differ significantly after BCT and mastectomy. Here we compare axillary lymph node dissection (ALND) and regional nodal irradiation (NRI) rates between women electing breast-conservation therapy (BCT) versus mastectomy.MethodsFrom 2010 to 2016, women age  
Source: Breast Cancer Research and Treatment - Category: Cancer & Oncology Source Type: research
AbstractPurposeTo estimate the performance of diffusion-weighted imaging (DWI) for breast cancer detection.MethodsConsecutive breast magnetic resonance imaging examinations performed from January to September 2016 were retrospectively evaluated. Examinations performed before/after neoadjuvant therapy, lacking DWI sequences or reference standard were excluded; breasts after mastectomy were also excluded. Two experienced breast radiologists (R1, R2) independently evaluated only DWI. Final pathology or  >  1-year follow-up served as reference standard. Mc Nemar, χ2, and κ statistics were applied.Res...
Source: Breast Cancer Research and Treatment - Category: Cancer & Oncology Source Type: research
ConclusionsImmediate latissimus dorsi flap reconstruction in selected patients with isolated breast tumor recurrence, which occurred after breast irradiation, provides an effective treatment with a satisfactory outcome.
Source: European Journal of Surgical Oncology (EJSO) - Category: Surgery Source Type: research
Objective: To evaluate a web-based breast reconstruction decision aid, BREASTChoice. Summary and Background Data: Although postmastectomy breast reconstruction can restore quality of life and body image, its morbidity remains substantial. Many patients lack adequate knowledge to make informed choices. Decisions are often discordant with patients’ preferences. Methods: Adult women with stages 0–III breast cancer considering postmastectomy breast reconstruction with no previous reconstruction were randomized to BREASTChoice or enhanced usual care (EUC). Results: Three hundred seventy-six patients were ...
Source: Annals of Surgery - Category: Surgery Tags: RANDOMIZED CONTROLLED TRIALS Source Type: research
ConclusionWe did not detect any inferiority of PRT/PRCT compared to a healthy reference group with no hints of a detrimental long-term effect on general and breast-specific quality of life.
Source: Strahlentherapie und Onkologie - Category: Cancer & Oncology Source Type: research
CONCLUSION: BCS is a safe alternative to TM in Latin-American patients with early-stage TNBC. PMID: 31903977 [PubMed - as supplied by publisher]
Source: Breast Disease - Category: Cancer & Oncology Tags: Breast Dis Source Type: research
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