Omega-3 fish oil doesn't reduce risk for early signs of colon cancer, study finds
In a trial results published in JAMA Oncology, researchers at the T.H. Chan School of Public Health at Harvard found that adding 1 gram per day of omega-3s fish oils failed to reduce development of colon polyps.
This study aimed to characterize the ATP-synthesis by oxidative phosphorylation in colorectal cancer (CRC) and premalignant colon polyps in relation to molecular biomarkers KRAS and BRAF. This prospective study included 48 patients. Resected colorectal polyps and postoperative CRC tissue with adjacent normal tissue (control) were collected. Patients with polyps and CRC were divided into three molecular groups: KRAS mutated, BRAF mutated and KRAS/BRAF wild-type. Mitochondrial respiration in permeabilized tissue samples was observed using high resolution respirometry. ADP-activated respiration rate (Vmax) and an apparent aff...
A collaboration between researchers at Nanyang Technological University, Harvard Medical School, and University of Alabama has led to the development of a prototype device capable of imaging through tissues at resolutions down to 1 micrometer (μm)...
ConclusionNo individual with MMR genetic disorder was identified by IHC screening of early-onset advanced colorectal adenomas. This strategy is therefore not an effective strategy for detecting MMR mutation carriers.
Conditions: Colorectal Cancer; Colorectal Polyp Intervention: Device: Colon capsule endoscopy Sponsor: Odense University Hospital Not yet recruiting
ConclusionsPatients with advanced colorectal polyps have poor knowledge of personal and familial CRC risk and recommendations. Endoscopists who remove advanced polyps are in an ideal position to educate their patients about their personal risk and the risk and recommendations for first-degree family members.
ConclusionWe described a protein truncation mutation, APC: p.W553X; demonstrated the value of APC-linked STR markers (D5S299, D5S134, and D5S346) haplotypes; and suggested the potential role of these haplotypes in detecting loss of heterozygosity of the APC gene.
AbstractBackgroundColonoscopies are considered to be the primary screening test and gold standard test for colorectal cancer. Position changes during colonoscope withdrawal are believed to be associated with an increased adenoma detection rate (ADR) and polyp detection rate (PDR). However, previous results conflicted, and this study aimed to elucidate the effectiveness of dynamic position changes during colonoscope withdrawal.MethodsThe relevant publications were identified by searching the medical databases. The primary outcomes were the ADR and PDR, which were pooled and analyzed. The secondary outcome was the withdrawal...
ConclusionOur results suggest that obesity might be an initiator for colon adenomas but not a promoter for colorectal cancer among Black women.