The 5-year Tysabri Global Observational Program in Safety (TYGRIS) study confirms the long-term safety profile of natalizumab treatment in multiple sclerosis

ConclusionData from this large, long-term study indicate that the nature, character, and frequency of SAEs in real-world settings are consistent with natalizumab's known safety profile. (Funded by Biogen; ClinicalTrials.gov identifiers: NCT00477113 and NCT00483847.)
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research

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Date: Tuesday, 12 17, 2019; Speaker: Dr. Erin Beck, NINDS; Dr. Kenneth Tyler, University of Colorado School of Medicine; Building: Building 10 (Clinical Center); Lipsett Auditorium; CME Credit
Source: NIH Calendar of Events - Category: American Health Source Type: events
CONCLUSION: The discrepancy between a clinical exam which is not indicative of thyrotoxicosis and markedly abnormal thyroid function tests should lead to a search for biotin intake, which can interfere with thyroid function tests. PMID: 31813616 [PubMed - as supplied by publisher]
Source: Revue de Medecine Interne - Category: Internal Medicine Tags: Rev Med Interne Source Type: research
Publication date: Available online 9 December 2019Source: NeuroImage: ClinicalAuthor(s): Richard McKinley, Rik Wepfer, Lorenz Grunder, Fabian Aschwanden, Tim Fischer, Christoph Friedli, Raphaela Muri, Christian Rummel, Rajeev Verma, Christian Weisstanner, Benedikt Wiestler, Christoph Berger, Paul Eichinger, Mark Muehlau, Mauricio Reyes, Anke Salmen, Andrew Chan, Roland Wiest, Franca WagnerAbstractThe detection of new or enlarged white-matter lesions is a vital task in the monitoring of patients undergoing disease-modifying treatment for multiple sclerosis. However, the definition of ‘new or enlarged’ is not fix...
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
We describe the gross and histological lesions found in 78 post-hatchling loggerhead sea turtles (Caretta caretta) that died during captive rearing in the conservation programme of the Cape Verde-Canary Islands, initiated with 113 hatchlings. The main organ systems affected were respiratory (57.69%), integumentary (41.02%) and digestive (41.02%), affecting 94.87% of the animals. Other less frequently affected organ systems were cardiovascular (3.85%), excretory (3.85%), muscular (2.56%) and reproductive (1.28%). The most common lesions were different types of dermatitis (41.02%), mainly ulcerative and/or heterophilic ulcer...
Source: Journal of Comparative Pathology - Category: Pathology Source Type: research
ConclusionsSeveral risk factors may play a role in evolution of MS. Our results show that smoking status, probably due to chronic vascular and neurotoxic effects of the cigarette components, can affect the brain damage from the early stages of MS. No association was observed with the other explored modifiable risk factors, although an effect due to the small sample size cannot be excluded.
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
ConclusionsET with scIFN β-1a tiw was associated with a higher likelihood of achieving NEDA-3 not only at 2 but also at 3 and 5 years.
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
Conclusion: Therapeutic inertia was observed in all pharmacist participants, affecting over fifty percent of MS treatment choices. Continuing education and specialization in MS may facilitate therapeutic decisions in MS care.
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
In this study, we investigated the effect of long-term 30% CR compared with ad libitum (AL) feeding on the microbiome in aging. We studied the Tg2576 model, where a mutant variant of the human APP is expressed in transgenic mice. This transgene results in cerebral amyloid accumulation, synaptic loss, and cognitive impairment by 12 months of age. We found that female Tg2576 mice have more substantial age-related microbiome changes compared to wildtype (WT) mice, including an increase in Bacteroides, which were normalized by CR. Specific gut microbiota changes were linked to Aβ levels, with greater effects in females th...
Source: Fight Aging! - Category: Research Authors: Tags: Medicine, Biotech, Research Source Type: blogs
UCLA scientists have discovered one reason why autoimmune diseases are more prevalent in women than in men. While males inherit their mother ’s X chromosome and father’s Y chromosome, females inherit X chromosomes from both parents. New research, which shows differences in how each of those X chromosomes is regulated, suggests that the X chromosome that females get from their father may help to explain their more active immune system .“It’s been known for many years that women are more susceptible to autoimmune diseases than men are,” said lead study author Dr. Rhonda Voskuhl, a UCLA professor...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news
Conclusion: The observed results revealed that the ZytuxTM could have a positive and significant effect on all types of MS.
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
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