Himatanthus bracteatus stem extracts present anti-flavivirus activity while an isolated sesquiterpene glucoside present only anti-Zika virus activity in vitro.

Himatanthus bracteatus stem extracts present anti-flavivirus activity while an isolated sesquiterpene glucoside present only anti-Zika virus activity in vitro.
Nat Prod Res. 2019 Nov 20;:1-5
Authors: da Silva ML, Stehmann JR, Serafim MSM, Vale VV, Gontijo DC, Brandão GC, Kroon EG, de Oliveira AB
Abstract
The hexane and ethanol extracts from Himatanthus bracteatus (Apocynaceae) stems were evaluated for antiviral activity against Zika virus, yellow fever virus and dengue virus 2 and for cytotoxicity in Vero cells by MTT assay. The ethanol extract showed good antiviral activity against the three viruses with selective indexes (SI) > 10 and its fractionation led to the isolation of the known plumieride that was active only against Zika virus (SI of 15.97).
PMID: 31746240 [PubMed - as supplied by publisher]

Source: Natural Product Research - November 19, 2019 Category: Biochemistry Authors: da Silva ML, Stehmann JR, Serafim MSM, Vale VV, Gontijo DC, Brandão GC, Kroon EG, de Oliveira AB Tags: Nat Prod Res Source Type: research