Heat Shock Protein Signaling in Brain Ischemia and Injury

Publication date: Available online 20 November 2019Source: Neuroscience LettersAuthor(s): Jong Youl Kim, Ji Won Kim, Midori A. YenariAbstractHeat shock proteins (HSPs) are chaperones that catalyze the refolding of denatured proteins. In addition to their ability to prevent protein denaturation and aggregation, the HSPs have also been shown to modulate many signaling pathways. Among HSPs, the inducible 70 kDa HSP (HSP70) has especially been shown to improve neurological outcome in experimental models of brain ischemia and injury. HSP70 can modulate various aspects of the programmed cell death pathways and inflammation. This review will focus on potential mechanisms of the neuroprotective effects of HSP70 in stroke and brain trauma models. We also comment on potential ways in which HSP70 could be translated into clinical therapies.
Source: Neuroscience Letters - Category: Neuroscience Source Type: research