New PtII triazol thiosemicarbazone' complexes. Analysis of their reactivity and potential antitumoral action.

We report the synthesis and characterization of three new platinum complexes using 3,5-diacetyl-1,2,4-triazol bis(4N-isopropylthiosemicarbazone) as a ligand. We describe the specific conditions in which solvent coordination takes place and we resolve the X-ray structure of the complex with one solvent molecule of dmso (dimethyl sulfoxide). The analysis of these platinum compounds' reactivity helped us find the best solution profile for the biological investigations. Then, we study the complexes' interaction with biological models such as CT DNA using UV spectroscopy and tracking the changes in the electrophoretic mobility produced in the supercoiled plasmid DNA model. Initial screening of these potential antitumoral compounds indicates possible selective antitumoral action.
PMID: 31746118 [PubMed - as supplied by publisher]

Source: Chembiochem - November 18, 2019 Category: Biochemistry Authors: Matesanz AI, Herrero J, Faraco EJ, Cubo L, Gomez Quiroga A Tags: Chembiochem Source Type: research