Molecules, Vol. 24, Pages 4239: Experimental Cannabinoid 2 Receptor Activation by Phyto-Derived and Synthetic Cannabinoid Ligands in LPS-Induced Interstitial Cystitis in Mice

This study used intravital microscopy (IVM) and behavioral testing in lipopolysaccharide-induced IC, to investigate the anti-inflammatory analgesic effects of a natural dietary sesquiterpenoid, beta-caryophyllene (BCP), which is present in cannabis among other plants, and has reported agonist actions at the cannabinoid 2 receptor (CB2R). BCP’s anti-inflammatory actions were compared to the synthetic CB2R-selective cannabinoid, HU308, and to an FDA-approved clinical treatment (dimethyl sulfoxide: DMSO). IVM data revealed that intravesical instillation of BCP and/or HU308 significantly reduces the number of adhering leukocytes in submucosal bladder venules and improves bladder capillary perfusion. The effects of BCP were found to be comparable to that of the selective CB2R synthetic cannabinoid, HU308, and superior to intravesical DMSO treatment. Oral treatment with BCP was also able to reduce bladder inflammation and significantly reduced mechanical allodynia in experimental IC. Based on our findings, we believe that CB2R activation may represent a viable therapeutic target for IC, and that drugs that activate CB2R, such as the generally regarded as safe (GRAS) dietary sesquiterpenoid, BCP, may serve as an adjunct and/or alternative treatment option for alleviating symptoms of inflammation and pain in the management of IC.
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research

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Conditions:   Chronic Interstitial Cystitis;   Bladder Pain Syndrome;   Cystitis, Interstitial;   Painful Bladder Syndrome;   Cystitis, Chronic Interstitial;   Interstitial Cystitis;   Interstitial Cystitis, Chronic;   Interstitial Cystitis (Chronic) With Hematuria;   Interstitial Cys titis (Chronic) Without Hematuria;   Chronic Prostatitis;   Chronic Prostatitis With Chronic Pelvic Pain Syndrome Interventions:   Behavioral: Psychosocial Treatment; &n...
Source: - Category: Research Source Type: clinical trials
AbstractIntroduction and hypothesisTo investigate the long-term feasibility, safety and effectiveness of intravesical chondroitin sulfate therapy in patients with one or more forms of chronic cystitis.MethodsThe study included 62 female patients with interstitial cystitis/painful bladder syndrome (IC/PBS) who received intravesical chondroitin sulfate (40 ml/80 mg) therapy between 2014 and 2018. A total of 15 doses of intravesical treatment were applied, once weekly in the first month and once monthly from the second month onward. A 3-day voiding diary, a visual analog scale (VAS), the O'Leary Sant Indexes (ICSI/ICPI), the ...
Source: International Urogynecology Journal - Category: OBGYN Source Type: research
ConclusionsA significant number of patients with IC are treated with opioids. Although the overall number of opioid prescriptions associated with IC had declined, the prescription rate per IC diagnosis had not. As part of the national initiative to reduce opioid use, our data suggest that IC treatment strategies should be examined.
Source: International Urogynecology Journal - Category: OBGYN Source Type: research
Publication date: Available online 17 January 2020Source: European UrologyAuthor(s): Kwang Jin Ko, Won Jin Cho, Young-Suk Lee, Joongwon Choi, Hye Jin Byun, Kyu-Sung LeeAbstractBackgroundInterstitial cystitis/bladder pain syndrome (IC/BPS) is a chronic condition characterized by chronic pelvic pain related to the bladder with no effective treatment options.ObjectiveTo evaluate the efficacy and safety of transurethral resection (TUR) and transurethral coagulation (TUC) as treatments for Hunner lesion (HL) in IC/BPS.Design, setting, and participantsA single-center, prospective, randomized controlled trial involving 126 patien...
Source: European Urology - Category: Urology & Nephrology Source Type: research
Patients with interstitial cystitis/bladder pain syndrome (IC/BPS) often grieve over a low quality of life brought about by chronic pain. In our previous studies, we determined that neuroinflammation of the sp...
Source: Journal of Neuroinflammation - Category: Neurology Authors: Tags: Research Source Type: research
AbstractPurpose of ReviewInterstitial cystitis/bladder pain syndrome (IC/BPS) is a chronic, potentially debilitating condition characterized by lower urinary tract symptoms and pain perceived to be related to the bladder. The etiology of IC/BPS has been rigorously studied for more than a century, but remains unknown. IC/BPS comprises a wide variety of clinical phenotypes with different potential etiologies. Recently, the importance of IC/BPS subtyping has become recognized. In this review, we revisit current hypotheses on IC/BPS pathophysiology and discuss the most likely causes of IC/BPS according to current research.Rece...
Source: Current Bladder Dysfunction Reports - Category: Urology & Nephrology Source Type: research
Abstract Aims: To assess the efficacy of a micronized-palmitoylethanolamide-polydatin (m-PEA-Pol) based product on chronic pelvic pain and severity of other symptoms in interstitial cystitis/bladder pain syndrome (IC/BPS) patients refractory to conventional therapies. Methods: A pilot, open-label bicentric study was carried out involving 32 IC/BPS patients. Chronic, oral m-PEA-Pol treatment lasted 6 months. Bladder pain was evaluated using the visual analog scale, while changes from baseline in other urinary symptoms were evaluated by means of the O'Leary-Sant Interstitial Cystitis Symptom and Problem Index a...
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
Abstract Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS) is a common chronic pelvic disorder with sensory symptoms of urinary urgency, frequency, and pain, indicating a key role for hypersensitivity of bladder-innervating sensory neurons. The inflammatory mast cell mediator histamine has long been implicated in IC/BPS, yet the direct interactions between histamine and bladder afferents remain unclear. Here we show, using a mouse ex vivo bladder afferent preparation, that intravesical histamine enhanced the mechanosensitivity of sub-populations of afferents to bladder distension. Histamine also recruited 'sile...
Source: American Journal of Physiology. Renal Physiology - Category: Physiology Authors: Tags: Am J Physiol Renal Physiol Source Type: research
ConclusionQualitative research has the potential to reveal and explain several aspects of CPP in women. The medical community may better accept knowledge gained from these studies if the methods are described more transparently in published articles.
Source: Archives of Gynecology and Obstetrics - Category: OBGYN Source Type: research
ConclusionsWomen with vulvodynia are substantially more likely to report voiding dysfunction and symptoms of urgency than women with no history of vulvar pain. These findings are independent of comorbid interstitial cystitis or history of UTIs.
Source: International Urogynecology Journal - Category: OBGYN Source Type: research
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