Clinical differences in sarcoidosis patients with and without lymphoma: a single-centre retrospective cohort analysis

Sarcoidosis is a systemic disease of unknown origin, characterised by the presence of noncaseating granulomas at disease sites [1]. A relevant clinical problem in the management of this disease is the coexistence of other clinical conditions, such as solid tumours or lymphomas, that may occur before or following the diagnosis of sarcoidosis, as well as simultaneously [2]. Particularly, the association of sarcoidosis and lymphoma is well established and was named the "sarcoidosis–lymphoma syndrome" by Brincker [3] and colleagues in 1986. In this syndrome, lymphoma occurs mainly in patients with a chronic active form of sarcoidosis, suggesting that chronic disease could be a risk factor for lymphoma. However, the distinctive clinical features of patients with sarcoidosis and lymphoma, and the precise mechanism underlying this association remain unclear.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Original Articles: Research letters Source Type: research