Experimental cholesterol-lowering drug effective at lowering bad cholesterol, study shows

PHILADELPHIA -- Twice-yearly injections of an experimental cholesterol-lowering drug, inclisiran, were effective at reducing low-density lipoprotein (LDL) cholesterol, often called bad cholesterol, in patients already taking the maximum dose of statin drugs, according to data of the ORION-10 trial presented Saturday, Nov. 16, at the American Heart Association's Scientific Sessions 2019. High levels of LDL [...]
Source: Mayo Clinic Research News - Category: Research Source Type: news

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COVID, sacubitril/valsartan, left atrial appendage occlusion, and statins are the topics Dr John Mandrola discusses in this week ’ s podcast.theheart.org on Medscape
Source: Medscape Cardiology Headlines - Category: Cardiology Tags: Cardiology Commentary Source Type: news
AbstractRosuvastatin/ezetimibe combines two lipid-lowering agents: rosuvastatin, an HMG-CoA reductase inhibitor (i.e. statin) with particularly strong inhibitory effects on hepatic cholesterol synthesis, and ezetimibe, which inhibits the intestinal absorption of cholesterol. A fixed-dose combination (FDC) of rosuvastatin/ezetimibe is indicated as an adjunctive therapy to diet for the management of primary hypercholesterolemia in adults in numerous countries worldwide. In well-designed clinical trials evaluating the therapeutic efficacy of rosuvastatin/ezetimibe administered as either separate agents or as an FDC, rosuvasta...
Source: American Journal of Cardiovascular Drugs - Category: Cardiology Source Type: research
AbstractIntroductionProprotein convertase subtilisin/kexin type 9 inhibitors (PCSK9i) are proven to have profound lowering of low-density lipoprotein cholesterol (LDL-C) in patients with clinical atherosclerotic cardiovascular disease or familial hypercholesterolemia.AimThe primary purpose of this study was to evaluate PCSK9i utilization in older adults, with a focus on efficacy outcomes within 6  months of initiation. Secondary outcomes included tolerability, out-of-pocket expenses (OPE), and barriers to initiation of therapy.MethodsWe conducted a retrospective chart review of patients ≥ 65 years prescribed P...
Source: High Blood Pressure and Cardiovascular Prevention - Category: Cardiology Source Type: research
Publication date: Available online 8 July 2020Source: Pharmacology &TherapeuticsAuthor(s): Ole Köhler-Forsberg, Christian Otte, Stefan M. Gold, Søren Dinesen Østergaard
Source: Pharmacology and Therapeutics - Category: Drugs & Pharmacology Source Type: research
With trial data for this age group in short supply, a US veterans cohort study saw a 25% drop in all-cause mortality for those newly starting on a statin at age 75 or older.Medscape Medical News
Source: Medscape Cardiology Headlines - Category: Cardiology Tags: Cardiology News Source Type: news
People 75 and older who were free of heart disease and prescribed a statin wound up with a 25% lower risk of death from any cause and a 20% lower risk of heart-related death, researchers reported July 7 in the Journal of the American Medical Association.
Source: WebMD Health - Category: Consumer Health News Source Type: news
Conclusion: The level of adherence to the recommendations of U.S. and Brazilian guidelines of dyslipidemia for statin use was low. Most patients used a moderate intensity statin, despite having a high cardiovascular risk. Simvastatin was the most prescribed statin. PMID: 32634034 [PubMed - as supplied by publisher]
Source: Current Medical Research and Opinion - Category: Research Tags: Curr Med Res Opin Source Type: research
AbstractPurpose of ReviewThe purpose of this review is to discuss the updated guideline recommendations on management of dyslipidemia for prevention and treatment of cardiovascular disease.Recent FindingsThe American College of Cardiology/American Heart Association (ACC/AHA) and European Society of Cardiology/European Atherosclerosis Society (ESC/EAS) published revised cholesterol management guidelines in 2018 and 2019, respectively, to reflect new evidence in the field. Broadly speaking, both emphasize refining cardiovascular disease risk estimation and aggressively lowering low-density lipoprotein-cholesterol (LDL-C) wit...
Source: Current Cardiology Reports - Category: Cardiology Source Type: research
Publication date: October 2020Source: Pharmacological Research, Volume 160Author(s): Wenhui Xie, Hong Huang, Shiyu Xiao, Xinlei Yang, Zhuoli Zhang
Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research
WEDNESDAY, July 8, 2020 -- In U.S. veterans aged 75 years and older, statin use is associated with reduced all-cause and cardiovascular mortality, according to a study published in the July 7 issue of the Journal of the American Medical...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
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