Optimizing The Management of Obese HFpEF Phenotype: Can We Mind Both The Heart and The Kidney?

Achieving effective and safe diuresis without compromising renal function is a primary goal of acute decompensated heart failure (ADHF) management. Cardiorenal syndrome represents the interdependent relation between the heart and kidneys during disease onset and progression. This important link between cardiac and renal pathophysiology is demonstrated by the high prevalence of chronic kidney disease (CKD) in patients with HF and vice versa. Dysfunction in both organs is strongly associated with increased morbidity and mortality.
Source: Journal of Cardiac Failure - Category: Cardiology Authors: Tags: Brief Report Source Type: research

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ConclusionsWe identified important differences in circulating biomarkers, cardiac/arterial characteristics, prognosis, and response to spironolactone across clinical HFpEF phenogroups. These findings suggest distinct underlying mechanisms across clinically identifiable phenogroups of HFpEF that may benefit from different targeted interventions.Central Illustration
Source: JACC: Heart Failure - Category: Cardiology Source Type: research
Conclusion A great deal of progress is being made in the matter of treating aging: in advocacy, in funding, in the research and development. It can never be enough, and it can never be fast enough, given the enormous cost in suffering and lost lives. The longevity industry is really only just getting started in the grand scheme of things: it looks vast to those of us who followed the slow, halting progress in aging research that was the state of things a decade or two ago. But it is still tiny compared to the rest of the medical industry, and it remains the case that there is a great deal of work yet to be done at all...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Conclusion A great deal of progress is being made in the matter of treating aging: in advocacy, in funding, in the research and development. It can never be enough, and it can never be fast enough, given the enormous cost in suffering and lost lives. The longevity industry is really only just getting started in the grand scheme of things: it looks vast to those of us who followed the slow, halting progress in aging research that was the state of things a decade or two ago. But it is still tiny compared to the rest of the medical industry, and it remains the case that there is a great deal of work yet to be done at all...
Source: Fight Aging! - Category: Research Authors: Tags: Of Interest Source Type: blogs
Silva, FCd, Iop, RdR, Andrade, A, Costa, VP, Gutierres Filho, PJB, and Silva, Rd. Effects of physical exercise on the expression of microRNAs: A systematic review 34(1): 270–280, 2020—Studies have detected changes in the expression of miRNAs after physical exercise, which brings new insight into the molecular control of adaptation to exercise. Therefore, the objective of the current systematic review of experimental and quasiexperimental studies published in the past 10 years was to assess evidence related to acute effects, chronic effects, and both acute and chronic effects of physical exercise on miRNA expres...
Source: Journal of Strength and Conditioning Research - Category: Sports Medicine Tags: Brief Review Source Type: research
Publication date: Available online 23 December 2019Source: Nutrition, Metabolism and Cardiovascular DiseasesAuthor(s): Xianfeng Wu, Guihua Jian, Yuezhong Tang, Huan Cheng, Niansong Wang, Junnan WuAbstractBackground and AimsAlthough hyperuricemia is associated with congestive heart failure (CHF), hyperuricemic patients frequently have other comorbidities. Thus, it is difficult to distinguish the role of hyperuricemia from that of other comorbid conditions in CHF. The aim of this study was to evaluate the association between hyperuricemia and CHF in elderly patients without comorbidities.MethodsSubjects aged ≥65 years wer...
Source: Nutrition, Metabolism and Cardiovascular Diseases - Category: Nutrition Source Type: research
IJERPH, Vol. 17, Pages 155: Important Considerations for the Treatment of Patients with Diabetes Mellitus and Heart Failure from a Diabetologist’s Perspective: Lessons Learned from Cardiovascular Outcome Trials International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17010155 Authors: Chrysi Koliaki Nicholas Katsilambros Heart failure (HF) represents an important cardiovascular complication of type 2 diabetes mellitus (T2DM) associated with substantial morbidity and mortality, and is emphasized in recent cardiovascular outcome trials (CVOTs) as a critical outcome for patients wit...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Editorial Source Type: research
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Background: Altered sleep quality has been reported in chronic kidney disease (CKD). However, most studies focused on dialyzed patients or were based on subjective reports that did not consider possible coexistence of obstructive sleep apnea (OSA).Aim: To evaluate, with a case-control design, if objective sleep quality differs between patients with stage 3 CKD and subjects with normal estimated glomerular filtration rate (eGFR) independent of sleep disordered breathing.Methods: In the European Sleep Apnea Database (ESADA) cohort, 527 patients who had undergone full polysomnography and had an eGFR60.Results: CKD patients we...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Sleep and control of breathing Source Type: research
The objective of this study was 1) to assess the relationship between diagnosed DLP and cardiovascular disease in COPD patients and compare it with other known cardiovascular risk factors and 2) to determine the relationship between the different cardiovascular comorbidities and the severity groups according to the GOLD 2017 classification.MethodsA cross-sectional, observational study was performed in 454 outpatients with COPD during their follow up. We calculated the prevalence of each of the cardiovascular comorbidities and the probability of each of the cardiovascular risk factors to occur jointly with a vascular diseas...
Source: Revista Clinica Espanola - Category: Internal Medicine Source Type: research
Discussion of Developmental Effects on Aging Microtubule Function and Longevity in Nematodes Quantifying the Correlation Between Poverty and Faster Pace of Aging Matthew O'Connor Presenting on Underdog Pharmaceuticals at Undoing Aging 2019 https://www.fightaging.org/archives/2019/09/matthew-oconnor-presenting-on-underdog-pharmaceuticals-at-undoing-aging-2019/ Here Matthew O'Connor of the SENS Research Foundation talks about the research that led to founding of Underdog Pharmaceuticals, a biotech startup incubated by the foundation to commercialize a means of targeting 7-ketocholesterol in atheroscleros...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
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