Feasibility and Safety of Low-Dose Intra-Coronary Tenecteplase During Primary Percutaneous Coronary Intervention for ST-Elevation Myocardial Infarction (ICE T-TIMI 49)

While primary percutaneous coronary intervention (PPCI) in ST-elevation myocardial infarction (STEMI) restores normal epicardial flow, limitations remain, including persistently impaired myocardial perfusion which in part is due to thrombotic embolization.1 This has been associated with worsened myocardial salvage2 and increased mortality.3 –5 Roughly one-quarter of patients will have impaired microvascular flow following reperfusion in STEMI.2 Moreover, distal embolization of intracoronary (IC) thrombus during mechanical intervention can lead to further infarct expansion.

Source: The American Journal of Cardiology - November 19, 2019 Category: Cardiology Authors: C. Michael Gibson, Varun Kumar, Lakshmi Gopalakrishnan, Priyamvada Singh, Jianping Guo, Samer Kazziha, Chandan Devireddy, Duane Pinto, J. Jeffrey Marshall, George A. Stouffer, Kreton Mavromatis, Laura Grip, Kevin R. Bainey, For the TIMI & PERFUSE Study G Source Type: research