Alterations in circulating T cell functional subpopulations in interferon-beta treated multiple sclerosis patients: A pilot study

Our work consists of a pilot study to characterize circulating Th/c1, Th/c2, Th/c17, Treg and Tfh-like populations and IL-17 serum levels of relapsing-remitting (RR) MS patients treated with IFN- β, compared with healthy controls.In remission RRMS patients, we observe increased Th/c17 cells frequency committed to a Th1 profile and increased soluble IL-17 levels. Moreover, a shift toward Th/c2 with reduction of Tc1 cells and decrease in effector/terminal differentiated compartment of Th1 cel ls were also observed.
Source: Journal of Neuroimmunology - Category: Allergy & Immunology Authors: Source Type: research