Bio-modified TiO2 nanoparticles with Withania somnifera, Eclipta prostrata and Glycyrrhiza glabra for anticancer and antibacterial applications

Publication date: Available online 20 November 2019Source: Materials Science and Engineering: CAuthor(s): P. Maheswari, S. Harish, M. Navaneethan, C. Muthamizhchelvan, S. Ponnusamy, Y. HayakawaAbstractTitanium dioxide nanoparticles exhibit good anticancer and antibacterial activities. They are known to be environmentally friendly and stable, less toxic and excellent biocompatibility nature. Due to these properties, they are well suited for biological applications particularly in biomedical applications such as drug delivery and cancer therapy. In this paper Pure TiO2 nanoparticles modified with Withania somnifera (Ashwagandha), Eclipta prostrata (Karisalankanni) and Glycyrrhiza glabra (Athimathuram) are examined for their biological applications. X-ray diffraction results revealed the anatase nature of the samples. From the TEM analyses, it is observed that there is an increase in the particle size of the bio modified samples. UV results show the red shift for the bio modified samples when compared with the pure samples. The samples are then subjected to MTT assay to determine the cell viability. KB oral cancer cells are used for the determination of anticancer nature of the Pure and bio modified nanoparticles. It is observed that Withania somnifera - Eclipta prostrate modified TiO2 nanoparticles exhibit excellent anticancer activities among other bio modified and pure samples. The samples are then examined for their antibacterial activities against three Gram-negative bacter...
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research