Risk Factors, Etiologies, and Screening Tools for Sepsis in Pregnant Women: A Multicenter Case-Control Study.

CONCLUSIONS: Chorioamnionitis and endometritis were the most common causes of sepsis, together accounting for about half of cases. Notable differences were observed in the sensitivity and specificity of sepsis screening tools with the highest to lowest sensitivity being SIRS, MEW, and qSOFA criteria, and the highest to lowest specificity being qSOFA, MEW, and SIRS. Mortality was doubled in the cohort of patients who received antibiotics after>1 hour. Clinicians need to be vigilant to identify cases of peripartum sepsis early in its course and prioritize timely antibiotic therapy. PMID: 31743182 [PubMed - in process]
Source: Anesthesia and Analgesia - Category: Anesthesiology Authors: Tags: Anesth Analg Source Type: research

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Publication date: Available online 25 January 2020Source: Anaesthesia &Intensive Care MedicineAuthor(s): Sarah L. Perrin, Christopher Bull, Sheila BlackAbstractLocal anaesthetics (LA) are weak bases consisting of a lipophilic aromatic ring linked to a hydrophilic tertiary amine by either an ester or amide bond. It is this chemical link that enables classification of the LA. They exist in solution as an equilibrium of ionized and unionized forms. The unionized form is free to diffuse across the axonal membrane, but it is the ionized form which then binds and blocks the intracellular portion of the voltage gated sodium c...
Source: Anaesthesia and intensive care medicine - Category: Anesthesiology Source Type: research
Publication date: Available online 25 January 2020Source: Anaesthesia &Intensive Care MedicineAuthor(s): Peter Carachi, Glyn WilliamsAbstractAcute pain management in the neonatal period remains a challenge for the clinician. Responses to pain and analgesic intervention are developmentally influenced and cannot be directly extrapolated from the older child. Successful and safe intervention will minimize acute physiological and behavioural distress, reduce pain scores and potentially improve short- and long-term outcomes. This requires an understanding of the physiology and pharmacology in this age group alongside a mult...
Source: Anaesthesia and intensive care medicine - Category: Anesthesiology Source Type: research
Publication date: Available online 25 January 2020Source: Anaesthesia &Intensive Care MedicineAuthor(s): Kylie McGregor, Saana TaylorAbstractAnaesthesia for term neonates is associated with increased perioperative morbidity and mortality and as a result should be reserved for specialized paediatric centres. Neonatal systems are immature and are undergoing rapid growth and development. Neonates are uniquely different in how they respond to surgery, drugs and fluids and this response varies across the neonatal period. Many of the physiological differences in neonates are a reflection of their high metabolic rate, increas...
Source: Anaesthesia and intensive care medicine - Category: Anesthesiology Source Type: research
Publication date: Available online 25 January 2020Source: Anaesthesia &Intensive Care MedicineAuthor(s): Geoff FrawleyAbstractAdvances in neonatal medicine have progressively increased the survival of premature infants. Increased survival has, however, come at the cost of increased number of infants with prematurity related complications. This is represented by high rates of respiratory distress syndrome, bronchopulmonary dysplasia, necrotising enterocolitis, sepsis, periventricular leukomalacia, intraventricular haemorrhage, cerebral palsy, hypoxic ischaemic encephalopathy and visual and hearing problems in survivors....
Source: Anaesthesia and intensive care medicine - Category: Anesthesiology Source Type: research
This article combines well-established and contemporary information to summarize a systems-based approach to traditional neonatal physiology.
Source: Anaesthesia and intensive care medicine - Category: Anesthesiology Source Type: research
Publication date: Available online 25 January 2020Source: Anaesthesia &Intensive Care MedicineAuthor(s): Graham Knottenbelt, Amanda DaltonAbstractSpecialist surgery in infancy provides challenges for paediatric anaesthetists. There is growing appreciation that the relatively higher rate of severe critical events in infants during the perioperative period requires appropriate competence, experience and resources for the safe conduct of anaesthesia. Both common (inguinal hernias and hypertrophic pyloric stenosis) and less common conditions (tracheo-oesophageal fistula, congenital diaphragmatic hernia, exomphalos, gastros...
Source: Anaesthesia and intensive care medicine - Category: Anesthesiology Source Type: research
Publication date: 1 April 2020Source: Materials Letters, Volume 264Author(s): Tauseef Munawar, Sadaf Yasmeen, Altaf Hussain, Muhammad Akram, Faisal IqbalAbstractIn this work, a novel antibacterial and photocatalytic material ZnO-Er2O3-Yb2O3 heterostructured nanocomposite was synthesized by facile co-precipitation technique. The antibacterial activity was performed against S. aureus and E. coli bacteria. The ZOI showed the nanocomposite has higher activity antibacterial against E. coli. The direct optical energy bandgap was 2.9 eV, specified it as a proficient photocatalyst under sunlight illumination. The grown nanoco...
Source: Materials Letters - Category: Materials Science Source Type: research
Publication date: Available online 25 January 2020Source: Biocybernetics and Biomedical EngineeringAuthor(s): Saqib Saleem, Ahmed Saeed, Shabnam Usman, Javed Ferzund, Jahangir Arshad, Jawad Mirza, Tareq ManzoorAbstractAccording to World Health Organization, 5—18% births around the world are premature, and this rate is on its rise. Recent trend has been to develop computational tools which could support obstetricians in their daily practice. This work is aimed at extracting novel diagnostic features for term vs. preterm births classification based on the dynamics of contraction and non-contractions (dummy) intervals. ...
Source: Biocybernetics and Biomedical Engineering - Category: Biomedical Engineering Source Type: research
Anti‑restriction protein KlcAHS enhances carbapenem resistance. Mol Med Rep. 2020 Feb;21(2):903-908 Authors: Liang W, Zhao C, Wang Y, Zhu W, Zhang Y, Hu J, Liu X, Yang L, Zhuang W, Shang Y, Huang G, Shi H Abstract The KlcAHS gene was previously identified as coexisting with the blaKPC‑2 gene in the backbone region of a series of blaKPC‑2‑harboring plasmids. The purpose of the present study was to determine the association between the KlcAHS and blaKPC‑2 genes. KlcAHS deletion and complementation experiments were used to evaluate the association between KlcAHS and carbapenem minimal inhibition...
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research
We reported that the apoptosis of liver cells after BD was significantly promoted than in the S group. Activation of ERS and PP2A was induced in the BD group when compared with S group. Phosphorylation of PP2A was suppressed in BD group. Application of 4‑PBA decreased the activation of ERS and apoptosis rate compared with the BD group. In addition, activation of PP2A in the BD + 4‑PBA group was decreased due to the reduction of PP2A phosphorylation compared with the BD group, but the levels were higher than in the S group. (P
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research
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