Prefrontal cortex alterations in glia gene expression in schizophrenia with and without suicide - Zhang L, Verwer RWH, Lucassen PJ, Huitinga I, Swaab DF.

BACKGROUND: Patients with schizophrenia (SCZ) run a lifelong risk of suicide. Alterations in glia activities in the prefrontal cortex (PFC) have been reported in relation to suicide in patients with SCZ. While immune processes in the CNS have been related ...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Ergonomics, Human Factors, Anthropometrics, Physiology Source Type: news

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Abstract Patients with schizophrenia (SCZ) exhibit higher suicide rates than the general population. However, the molecular mechanism remains poorly understood. Tumor necrosis factor (TNF)-alpha polymorphisms have been repeatedly indicated to play a pathogenetic role in various mental disorders, but none of these studies focused on the susceptibility to suicidal behavior in SCZ. We recruited 1087 chronic inpatients with SCZ and 576 controls to assess the psychopathological symptoms of SCZ using the Positive and Negative Syndrome Scale scales. We selected 2 polymorphisms (-308G>A and -1031C>T) in the TNF-alph...
Source: Aging - Category: Biomedical Science Authors: Tags: Aging (Albany NY) Source Type: research
Long-term antipsychotic use is associated with substantially decreased mortality compared with no antipsychotic use, especially among patients treated with clozapine, according to areport inWorld Psychiatry, the journal of the World Psychiatric Association.Moreover, long ‐term antipsychotic use does not increase the likelihood that a patient will experience severe illness leading to hospitalization, wrote Heidi Taipale, Ph.D., of the Karolinska Institute in Sweden and colleagues.People with schizophrenia have a shorter average life expectancy than the general population. Taipale and colleagues wanted to know if these dif...
Source: Psychiatr News - Category: Psychiatry Tags: antipsychotics death Heidi Taipale hospitalization long-term use schizophrenia side effects suicide World Psychiatry Source Type: research
Suicide risk in schizophrenia is a significant treatment challenge but there are few approved treatments. Electroconvulsive therapy (ECT) is a highly effective treatment for suicidality in depression but its effect on suicidality in schizophrenia is unclea...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Program and Other Evaluations, Effectiveness Studies Source Type: news
OBJECTIVES: Previous studies have shown that cognitive impairment plays a key role in suicide, an important factor leading to premature death in schizophrenia (SCZ) patients. Empathy has received extensive attention recently; however, the relationship of e...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Risk Factor Prevalence, Injury Occurrence Source Type: news
honen J Abstract Antipsychotics are effective in preventing relapses of schizophrenia, but it is generally believed that their long-term use is harmful for patients' physical well-being. However, there are no long-term studies which have verified this view. This nationwide, register-based cohort study aimed to assess the risk of hospitalization due to physical health problems, as a marker for severe physical morbidity, and the risk of all-cause mortality, as well as of cardiovascular and suicidal death, associated with antipsychotic use in all patients treated for schizophrenia in inpatient care between 1972 and 2...
Source: World Psychiatry - Category: Psychiatry Authors: Tags: World Psychiatry Source Type: research
Publication date: Available online 10 January 2020Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Wenjia Wang, Yongjie Zhou, Jiesi Wang, Hang Xu, Shuochi Wei, Dongmei Wang, Li Wang, Xiangyang ZhangAbstractObjectivesPrevious studies have shown that cognitive impairment plays a key role in suicide, an important factor leading to premature death in schizophrenia (SCZ) patients. Empathy has received extensive attention recently; however, the relationship of empathy with suicide in schizophrenia is still unknown. The main aim of this study was to investigate the prevalence of suicide attempts an...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - Category: Psychiatry Source Type: research
Conditions:   Schizophrenia;   Suicide Interventions:   Behavioral: Enhanced Treatment as Usual;   Behavioral: Coping Long-term with Active Suicide Program for Schizophrenia Sponsors:   Butler Hospital;   American Foundation for Suicide Prevention Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
BACKGROUND: Depression is common among people with schizophrenia and associated with severe positive and negative symptoms, higher rates of disability, treatment resistance and mortality related to suicide, physical and drug-related causes. However, to our...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Risk Factor Prevalence, Injury Occurrence Source Type: news
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