Novel ethanol-sensitive mutants identified in an F3 forward genetic screen.

CONCLUSIONS: The phenotypes of these ethanol-sensitive mutants differ from those in previous characterizations of gene-ethanol interactions. Thus, each mutant is likely to provide novel insights into ethanol teratogenesis. Given that most of these mutants only have craniofacial defects in the presence of ethanol and our mapping of au29, it is also likely that many of the mutants will be previously uncharacterized. Collectively, our findings point to the importance of unbiased genetic screens in the identification, and eventual characterization, of risk alleles for FASD. PMID: 31742718 [PubMed - as supplied by publisher]
Source: Alcoholism, Clinical and Experimental Research - Category: Addiction Authors: Tags: Alcohol Clin Exp Res Source Type: research

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Publication date: Available online 23 January 2020Source: NeuroscienceAuthor(s): Brian A. Coffman, Felicha T. Candelaria-Cook, Julia M. StephenAbstractWhile it is generally accepted that structural and functional brain deficits underlie the behavioral deficits associated with fetal alcohol spectrum disorders (FASD), the degree to which these problems are expressed in sensory pathology is unknown. Electrophysiological measures indicate that neural processing is delayed in visual and auditory domains. Furthermore, multiple reports of white matter deficits due to prenatal alcohol exposure indicate altered cortical connectivit...
Source: Neuroscience - Category: Neuroscience Source Type: research
Publication date: April 2020Source: Research in Autism Spectrum Disorders, Volume 72Author(s): Daniel E. Lidstone, Faria Z. Miah, Brach Poston, Julie F. Beasley, Janet S. DufekAbstractBackgroundPostural control deficits are commonly reported in children with Autism Spectrum Disorder (ASD). However, identification of specific postural sway features that differentiate ASD from other neurodevelopmental disorders has not been examined. The current study employs a cross-syndrome approach by comparing postural sway area and direction-specific features of sway magnitude, sway velocity, and sway complexity between children with AS...
Source: Research in Autism Spectrum Disorders - Category: Psychiatry Source Type: research
You’ve done it! You’ve taken that last birth control pill, removed your IUD, or stopped using your contraceptive method of choice. You’ve made the decision to try to conceive a pregnancy, and while this is an exciting time in your life, it can also feel overwhelming. There is so much advice around fertility and pregnancy, and sifting through it all just isn’t possible. For many mothers, their goals crystallize around ensuring that their baby is healthy. Evidence-based steps that may prevent birth defects January is Birth Defects Prevention Month, so we want to focus on things you can do to reduce th...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Family Planning and Pregnancy Fertility Vaccines Women's Health Source Type: blogs
Manitoba's new FASD court is designed for people like Everett Redhead, who has some of the wide-ranging symptoms of fetal alcohol spectrum disorders. CBC News followed him from his first court date in April to sentencing.
Source: CBC | Health - Category: Consumer Health News Tags: News/Canada/Manitoba Source Type: news
Legal experts in Manitoba’s new court to help offenders with fetal alcohol spectrum disorder (FASD) say demand for the docket has skyrocketed since its launch, leading to long wait times and plans to expand.
Source: CBC | Health - Category: Consumer Health News Tags: News/Canada/Manitoba Source Type: news
Publication date: 10 February 2020Source: Neuroscience, Volume 427Author(s): Alessandro Ieraci, Daniel G. HerreraAbstractDrinking alcohol during pregnancy is particularly detrimental for the developing brain and may cause a broad spectrum of cognitive and behavioral impairments, collectively known as fetal alcohol spectrum disorder (FASD). While behavioral abnormalities and brain damage have been widely investigated in animal models of FASD, the sex differences in the vulnerability to perinatal ethanol exposure have received less consideration. Here we investigated the long-term behavioral and molecular effects of acute et...
Source: Neuroscience - Category: Neuroscience Source Type: research
We examined age-related differences in the volume of the corpus callosum, basal ganglia, and cerebellum across adolescence and young adulthood, due to the sensitivity of these regions to prenatal alcohol exposure. T1-weighted anatomical magnetic resonance images (MRI) were acquired from a cross-sectional sample of subjects 13-30 years old who had received an alcohol-related diagnosis (FASD, n=107) and typically developing controls (CON, n=56). FreeSurfer v5.3 was used to obtain volumetric data for the corpus callosum, caudate, putamen, pallidum, and cerebellum. Analysis of variance (ANOVA) was used to examine the effects o...
Source: Brain Research - Category: Neurology Authors: Tags: Brain Res Source Type: research
To investigate whether ophthalmological findings in children with fetal alcohol spectrum disorders (FASD) persist into young adulthood.
Source: American Journal of Ophthalmology - Category: Opthalmology Authors: Tags: Original Articles Source Type: research
BACKGROUND: Binge drinking (BD) is a serious risk factor for fetal alcohol spectrum disorders (FASD) and associated with more severe forms of the disorder. Thus, special attention to specific risk factors for BD adjacent to and during pregnancy is warrante...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
Publication date: Available online 7 January 2020Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Amanda Facciol, Celine Bailleul, Samuel Nguyen, Robert GerlaiAbstractFASD results from the developing fetus being exposed to alcohol, and is characterized by morphological, behavioural and cognitive deficits. However, the expression, severity and age of onset of these symptoms has been found to show variation. This variation may partly be due to the developmental stage at which alcohol reached the developing fetus. Previously, alcohol was shown to lead to significant concentration dependent beha...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - Category: Psychiatry Source Type: research
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