Novel ethanol-sensitive mutants identified in an F3 forward genetic screen.

CONCLUSIONS: The phenotypes of these ethanol-sensitive mutants differ from those in previous characterizations of gene-ethanol interactions. Thus, each mutant is likely to provide novel insights into ethanol teratogenesis. Given that most of these mutants only have craniofacial defects in the presence of ethanol and our mapping of au29, it is also likely that many of the mutants will be previously uncharacterized. Collectively, our findings point to the importance of unbiased genetic screens in the identification, and eventual characterization, of risk alleles for FASD. PMID: 31742718 [PubMed - as supplied by publisher]
Source: Alcoholism, Clinical and Experimental Research - Category: Addiction Authors: Tags: Alcohol Clin Exp Res Source Type: research