Severe Asymptomatic Carotid Stenosis is Associated with Robust Reductions in Homotopic Functional Connectivity

Publication date: Available online 20 November 2019Source: NeuroImage: ClinicalAuthor(s): Lei Gao, Tao Wang, Tianyi Qian, Feng Xiao, Lijun Bai, Junjian Zhang, Haibo XuAbstractSevere (> 70% narrowing) asymptomatic carotid stenosis (SACS) is associated with cognitive impairment and future strokes, and connectivity basis for the remote brain consequences is poorly understood. Here we explored homotopic connectivity and parenchymal lesions measured by multimodal magnetic resonance imaging (MRI) parameters in patients with SACS. Twenty-four patients with SACS (19 males/ 5 females; 64.25 ± 7.18 years), 24 comorbidities-matched controls (19 males/ 5 females; 67.16 ±6.10 years), and an independent sample of elderly healthy controls (39 females/45 males; 57.92 ± 4.94 years) were included. Homotopic functional connectivity (FC) of resting-state functional MRI and structural connectivity (SC) of deterministic tractography were assessed. Arterial spin labeling based cerebral perfusion, susceptibility weighted imaging based microhemorrhagic lesions, and T2-weighted white matter hyperintensities were also quantified. Significant and robust homotopic reductions (validated by the independent dataset and support vector machine-based machine learning) were identified in the Perisylvian fissure in patients with SACS (false discovery rate corrected, p
Source: NeuroImage: Clinical - Category: Radiology Source Type: research

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Conclusions: This pilot study demonstrated the feasibility of a metacognitive occupation-based telerehabilitation intervention and its potential benefits in activity performance, participation, and QoL for older adults coping with long-term disability following ABI.Clinical Trial Registration: www.ClinicalTrials.gov, identifier: NCT03048708.
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Conclusions: Our results suggest that in this community-dwelling population, a higher CAA score is related to cognitive impairment and a higher risk of stroke, dementia, and death. The composite CAA score can be used to practically quantify the severity of vascular brain injury.
Source: Frontiers in Neurology - Category: Neurology Source Type: research
ConclusionCognitive impairment and dementia affected almost one-third of patients, whether assessed pre or post ICH.
Source: Neurological Sciences - Category: Neurology Source Type: research
Drinking alcohol causes damage to your health in both the short term and long term, even for moderate drinkers. For individuals who suffer from addiction to alcohol and frequently drink in excess, these risks become higher. Knowing the risks of drinking alcohol is important to help avoid drinking to excess and reduce the likelihood of these risks. Short-Term Risks of Drinking Alcohol There are many short-term risks that occur when drinking alcohol. These risks can happen to anyone, including individuals suffering from alcohol use disorder, or individuals who are drinking for the very first time. Injuries When you drink al...
Source: Cliffside Malibu - Category: Addiction Authors: Tags: Alcoholism alcohol abuse alcohol dependence alcohol dependency alcohol detox alcohol treatment alcohol treatment center alcohol treatment facility alcohol use risks Source Type: blogs
Introduction: Carotid endarterectomy (CEA) might protect against dementia by reducing future stroke risk and improving cerebral blood flow. Using linkage of randomised trial participants to electronic health records, we aimed to measure the long-term effect of CEA on stroke and on recorded dementia in ACST-1 (ISRCTN26156392).
Source: European Journal of Vascular and Endovascular Surgery - Category: Surgery Authors: Source Type: research
Abstract Atrial fibrillation (AF) is the most common arrhythmia encountered in clinical practice with implications on long-term outcomes. Metabolic disorders including diabetes mellitus and obesity are independent predictors of atrial fibrillation and present therapeutic targets to reduce both the incidence and duration burden of atrial fibrillation. The presence of pericardial fat in direct contact with cardiac structures, as well the subsequent release of proinflammatory cytokines, may play an important role in this connection. Atrial fibrillation is an independent predictor of cognitive impairment and dementia....
Source: Medicina (Kaunas) - Category: Universities & Medical Training Authors: Tags: Medicina (Kaunas) Source Type: research
As people age, they generally become hard to buy gifts for, often because they are in the process of weeding through their belongings and need so little. Also, many have issues with their health ranging from arthritic pain to cognitive disorders which influence what they can use. Still, we want to include them in holiday giving. What to do? Here are some practical, but still enjoyable, ideas. (Prices are not included, as some products may vary depending on the retailer you choose.) Continue reading on HealthCentral to learn more about possible gifts for older adults in your life as well as someone who lives with dementia. ...
Source: Minding Our Elders - Category: Geriatrics Authors: Source Type: blogs
Photo credit Melanie Wasser Dear Carol: My mother developed vascular dementia, personality issues, and speech problems after a stroke three years ago. She lives with me, and because of her difficult personality, my daughter no longer wants to bring my grandchildren here to visit. I retired early to care for Mom, but now I feel trapped. Nothing I do for her is right. I’ve suggested that she might have a better life if she moved to assisted living and, surprisingly, she isn’t resistant — though I know she’ll complain about them, too, if she moves. My sisters live out of the area, so they are limi...
Source: Minding Our Elders - Category: Geriatrics Authors: Source Type: blogs
CONCLUSION: The optimal management of modifiable risk factors may be important for preventing dementia in subjects with diabetes mellitus. PMID: 31769236 [PubMed - as supplied by publisher]
Source: Diabetes and Metabolism Journal - Category: Endocrinology Tags: Diabetes Metab J Source Type: research
AbstractStroke and Alzheimer ’s disease (AD) are cerebral pathologies with high socioeconomic impact that can occur together and mutually interact. Vascular factors predisposing to cerebrovascular disease have also been specifically associated with development of AD, and acute stroke is known to increase the risk to develop d ementia.Despite the apparent association, it remains unknown how acute cerebrovascular disease and development of AD are precisely linked and act on each other. It has been suggested that this interaction is strongly related to vascular deposition of amyloid- β (Aβ), i.e., cerebral amy...
Source: Translational Stroke Research - Category: Neurology Source Type: research
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