Diagnosis, pathophysiology, management and future issues of trigeminal surgical nerve injuries

AbstractThe trigeminal nerve constitutes the largest sensory cortex representation in the brain compared with other sensory nerves. This is likely due to the fact that the trigeminal nerve underpins our very existence, as it sensorially protects, our five senses including the organs that provide sight, smell, taste, hearing, speech and meninges protecting our brain.Thus, when trigeminal nerve injuries occur, which in the main are preventable and painful, the majority of patients experience mixed symptoms including altered sensation, numbness, and ongoing or elicited neuropathic pain. These neuropathic features cause significant impact on the patients ’ ability to function, for example cold allodynia prevents the patient enjoying cold foods and drinks and undertaking out‚Äźdoor activities or mechanical allodynia frequently interferes with eating, speaking, kissing and sleep. The resultant chronic symptoms and functional impedance results in sig nificant psychological morbidity.Prevention of nerve injuries related to local anaesthesia, endodontics, implants and third molar surgery is imperative as there is no magic bullet to repair these sensory nerve injuries with their related neuropathic pain. Some causes have higher levels of resolution (third molar surgery and local anaesthesia) some lower levels of resolution (implant surgery and endodontics) and many patient factors will dictate the prevalence of chronic neuropathic pain. The patient must have appropriate consent a...
Source: Oral Surgery - Category: ENT & OMF Authors: Tags: ORIGINAL ARTICLE Source Type: research

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Patients with chronic pain often report being sensitive to pain at night before falling asleep, a time when the synchronization of cortical activity is initiated. However, how cortical activity relates to pain sensitivity is still unclear. Because sleep is characterized by enhanced cortical delta power, we hypothesized that enhanced cortical delta power may be an indicator of intensified pain. To test this hypothesis, we used pain thresholds tests, EEG/electromyogram recordings, c-Fos staining, and chemogenetic and pharmacological techniques in mice. We found that sleep deprivation or pharmacologic enhancement of EEG delta...
Source: Pain - Category: Anesthesiology Tags: Research Paper Source Type: research
Comorbidity is the presence of one or more additional conditions co-occurring with a primary condition. In this episode, host schizophrenic Rachel Star Withers with her cohost Gabe Howard will be discussing comorbidity with schizophrenia. Comorbidity is associated with worse health outcomes, more complex clinical management and increased health care costs. Occupational therapist and host of the podcast Occupied, Brock Cook, will be joining us to discuss ways that he works with people with schizophrenia to manage multiple health issues.  Highlights from “Comorbidity with Schizophrenia” Episode [01:28] What ...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Antipsychotic Inside Schizophrenia Mental Health and Wellness Psychiatry Psychology Psychotherapy Bipolar disorder and schizophrenia comorbid comorbid psychiatric conditions Comorbidities Comorbidity Diagnosis Of Schizophrenia Livi Source Type: blogs
ConclusionThis study provides evidence that ME/CFS has a profound and negative impact on HRQoL in an Australian cohort.
Source: Quality of Life Research - Category: Health Management Source Type: research
Compared with placebo, cannabinoids show no improvement in pain scores in adult cancer patients
Source: The Doctors Lounge - Oncology - Category: Cancer & Oncology Tags: Oncology, Pharmacy, Anesthesiology & amp; Pain, Journal, Source Type: news
TUESDAY, Jan. 21, 2020 -- Medical marijuana may not provide long-term relief of sleep issues in people battling chronic pain, a new study finds, mainly because users may develop a tolerance to the drug. The finding is important " considering the...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
TUESDAY, Jan. 21, 2020 -- For patients with chronic pain, medical cannabis (MC) use has a positive effect on maintaining sleep; however, cannabinoids do not appear to reduce cancer pain, according to a study and review published online Jan. 20 in...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
Researchers at the University of Israel assessed the sleep quality and levels of pain of 128 people over 50 being treated at a specialist clinic.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
(BMJ) Medicinal cannabis might not ease sleep problems in people with chronic pain over the long term, because frequent users might build up tolerance to its sleep-inducing effects, suggests preliminary research published online in BMJ Supportive&Palliative Care.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
AbstractMorbidly obese individuals often require surgery, including bariatric (weight management) surgery. Acute pain management in the morbidly obese must consider the risk of chronic post-surgical pain, opioid dependence, and comorbidities (e.g. sleep-disordered breathing). A stepped, multimodal, opioid-sparing approach titrated to the type and severity of pain type should be taken, with co-administration of systemic and local anaesthetic agents when appropriate.
Source: Drugs and Therapy Perspectives - Category: Drugs & Pharmacology Source Type: research
DiscussionThere is a scarcity of psychological interventions for depression targeting the newly diagnosed period. However, interventions during this time point have the potential to have a major impact on the mental and physical wellbeing of those newly diagnosed with MS. The current trial will provide data on the effectiveness of a tailored CBT intervention for the treatment of depression in those newly diagnosed with MS. Findings will also provide effect size estimates that can be used to power a later-stage multi-centre trial of treatment efficacy, and will provide information on the mechanisms underlying any treatment ...
Source: Trials - Category: Research Source Type: clinical trials
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