GSE140650 miRNA profiling of peripheral blood mononuclear cells from AIDS patients and healthy control group

Contributors : Quansheng Feng ; Xiao LiSeries Type : Non-coding RNA profiling by arrayOrganism : Homo sapiensWith the purpose of identifying the cascaded miRNA-mRNA regulatory relationships related to infection of HIV in gene level, we extracted mRNA from Peripheral blood mononuclear cells from 50 AIDS patients and 7 uninfected health controls. All AIDS patients in sample were received Antiretroviral Therapy. To further analysis the miRNA expression pattern in different virus load, we classified high virus loads (HVL, n=14) and low virus loads (LVL, n=16). 145 and 129 differentially expressed miRNAs (DEMs) were selected, respectively in LVL and HVL. Functional enrichment analysis indicated miRNA-correlated targets which involved in immune response and apoptosis, played a crucial role in HIV infection. Further, we identified 5 most influential TFs to build miRNA-TF-mRNA regulatory network.

Source: GEO: Gene Expression Omnibus - November 20, 2019 Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by array Homo sapiens Source Type: research