Cancers, Vol. 11, Pages 1826: Molecular Targeting Therapy against EGFR Family in Breast Cancer: Progress and Future Potentials

Cancers, Vol. 11, Pages 1826: Molecular Targeting Therapy against EGFR Family in Breast Cancer: Progress and Future Potentials Cancers doi: 10.3390/cancers11121826 Authors: Maennling Tur Niebert Klockenbring Zeppernick Gattenlöhner Meinhold-Heerlein Hussain :The epidermal growth factor receptor (EGFR) family contains four transmembrane tyrosine kinases (EGFR1/ErbB1, Her2/ErbB2, Her3/ErbB3 and Her4/ErbB4) and 13 secreted polypeptide ligands. EGFRs are overexpressed in many solid tumors, including breast, pancreas, head-and-neck, prostate, ovarian, renal, colon, and non-small-cell lung cancer. Such overexpression produces strong stimulation of downstream signaling pathways, which induce cell growth, cell differentiation, cell cycle progression, angiogenesis, cell motility and blocking of apoptosis.The high expression and/or functional activation of EGFRs correlates with the pathogenesis and progression of several cancers, which make them attractive targets for both diagnosis and therapy. Several approaches have been developed to target these receptors and/or the EGFR modulated effects in cancer cells. Most approaches include the development of anti-EGFRs antibodies and/or small-molecule EGFR inhibitors. This review presents the state-of-the-art and future prospects of targeting EGFRs to treat breast cancer.
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research

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Authors: Cao M, Zhou M, Zhang J Abstract Patients with metastatic colorectal cancer (mCRC) beyond second line treatment have a poor prognosis. Regorafenib, TAS-102, fruquintinib, panitumumab and cetuximab are recommended single-agent chemotherapy regimens for patients exhibiting disease progression, this meta-analysis aimed to evaluate the efficacy and safety of these regimens in randomized controlled trials (RCTs). Eight RCTs with 3,832 cancer patients were included. Results showed that there was no significant difference in OS and PFS among the four drugs when comparing all patients or patients who have the KRAS ...
Source: Journal of Chemotherapy - Category: Cancer & Oncology Tags: J Chemother Source Type: research
CONCLUSION: The best of our knowledge it is the third description of brachial plexus schwannoma associated with breast cancer and the first with a synchronous association. The knowledge of this pathology and its potential to alter treatment justify the reporting of the present case. PMID: 32083563 [PubMed - as supplied by publisher]
Source: Breast Disease - Category: Cancer & Oncology Tags: Breast Dis Source Type: research
In this study, dosimeters were used to measure the testicular dose with and without testicular shielding to verify the effect of shielding. Anthropomorphic phantoms representing a human were used to estimate the doses absorbed in testicular and whole-body studies. The anthropomorphic phantom was irradiated according to the treatment protocol for colorectal cancer. Measurements were made using optically-stimulated luminescent dosimeters (OSLDs), composed of carbon-doped aluminum oxide, with characteristics suitable for radiotherapy dosimetry studies. A set of OSLDs was placed on a testicular phantom, attached to the lower e...
Source: Radiation Physics and Chemistry - Category: Physics Source Type: research
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Source: Clinical Colorectal Cancer - Category: Cancer & Oncology Authors: Tags: Clin Transl Immunology Source Type: research
Authors: Herold A Abstract Hemorrhoidal disease is one of the most common illnesses in industrialized nations. Up to 70% of adults suffer from the disease once in their lifetime. This underlines the necessity and importance of knowing about the differential diagnosis of hemorrhoids. One can differentiate between differential diagnoses of symptoms (bleeding, pain, itching, tumor) and differential diagnoses of the phenotype findings (anal prolapse, mucosal prolapse and rectal prolapse, skin tags, hypertrophied anal papillae, condylomata acuminata, anal fissure, perianal venous thrombosis, anal cancer). PMID: 3207...
Source: Der Hautarzt: Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete - Category: Dermatology Tags: Hautarzt Source Type: research
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Source: Life Sciences - Category: Biology Source Type: research
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Source: Life Sciences - Category: Biology Source Type: research
In this study, fluorescence emission spectroscopy and mass spectrometry (MALDI-TOF) were employed to define the putative interaction sites and their accessibility for the biologically important metals of Irving William Series.Key findingsSeveral hotspot residues in the ZAG scaffold involved in these interactions were mapped and their binding affinity score for each metal has been determined. Their binding abilities of these sites and aggregation propensities of ZAG were monitored by fluorescence emission spectroscopy.SignificanceThe prediction of such binding affinity with metals on the active sites and its impact on the c...
Source: Life Sciences - Category: Biology Source Type: research
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Source: Polymer - Category: Chemistry Source Type: research
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Source: Chinese Chemical Letters - Category: Chemistry Source Type: research
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