SIRT4 silencing in tumor-associated macrophages promotes HCC development via PPAR δ signalling-mediated alternative activation of macrophages

The activation of tumour-associated macrophages (TAMs) contributes to the progression of hepatocellular carcinoma (HCC). SIRT4 acts as a tumour suppressor of tumour growth by regulating cell metabolism, inflam...

Source: Journal of Experimental and Clinical Cancer Research - November 19, 2019 Category: Cancer & Oncology Authors: Zhi Li, He Li, Zhi-Bo Zhao, Wei Zhu, Pan-Pan Feng, Xi-Wen Zhu and Jian-Ping Gong Tags: Research Source Type: research