Natural products discovery and potential for new antibiotics.

Natural products discovery and potential for new antibiotics. Curr Opin Microbiol. 2019 Nov 15;51:81-87 Authors: Genilloud O Abstract Microbial natural products have been one of the most important sources for the discovery of potential new antibiotics. However, the decline in the number of new chemical scaffolds discovered and the rediscovery problem of old known molecules has become a limitation for discovery programs developed by an industry confronted by a lack of incentives and a broken economic model. In contrast, the emergence of multidrug resistance in key pathogens has continued to progress and this issue is compounded by a lack of new antibiotics in development to address most of the difficult to treat infections. Advances in genome mining have confirmed the richness of biosynthetic gene clusters (BGCs) in the majority of microbial sources, and this suggests that an untapped chemical diversity is waiting to be discovered. The development of new genome engineering and synthetic biology tools, and the implementation of comparative omic approaches is fostering the development of new integrated culture-based strategies and genomic-driven approaches aimed at delivering new chemical classes of antibiotics. PMID: 31739283 [PubMed - as supplied by publisher]
Source: Current Opinion in Microbiology - Category: Microbiology Authors: Tags: Curr Opin Microbiol Source Type: research

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Publication date: Available online 23 January 2020Source: Pharmacological ResearchAuthor(s): Su-Wei Xu, Betty Yuen Kwan Law, Steven Li Qun Qu, Sami Hamdoun, Juan Chen, Wei Zhang, Jian-Ru Guo, An-Guo Wu, Simon Wing Fai Mok, David Wei Zhang, Chenglai Xia, Yoshikazu Sugimoto, Thomas Efferth, Liang Liu, Vincent Kam Wai WongAbstractMultidrug resistance (MDR) represents an obstacle in anti-cancer therapy. MDR is caused by multiple mechanisms, involving ATP-binding cassette (ABC) transporters such as P-glycoprotein (P-gp), which reduces intracellular drug levels to sub-therapeutic concentrations. Therefore, sensitizing agents ret...
Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research
Gram-negative rod bacteremia (GNRB) is a leading cause of morbidity and mortality among allogeneic hematopoietic cell transplant (HCT) recipients. Historically, GNRB has been treated with inpatient intravenous antibiotic therapies. However, outpatient antibiotic delivery has been shown to lower costs, decrease complications and may reduce rates of hospital-acquired multidrug-resistant organism (MDRO) infections. Despite such advantages, there are no data assessing trends in outpatient management of GNRB among allogeneic HCT recipients nor on the impact changing resistance profiles have on such trends.
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Tags: 492 Source Type: research
CONCLUSIONS Our findings suggest that Trop2 promotes the resistance of gastric cancer to chemotherapy by activating the Notch1 pathway. PMID: 31964857 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
Publication date: Available online 22 January 2020Source: PeptidesAuthor(s): Anshul Panjeta, Simran PreetAbstractThe escalating predicament of multidrug resistant cancer cells and associated side effects of conventional chemotherapy necessitates the exploration of alternative anticancer therapies. The present study evaluated anticancer therapeutic potential of human defensin 5 (HD-5) against colon cancer. The in vivo anticancer efficacy of HD-5 against 1,2-dimethylhydrazine (DMH) induced colon cancer was elucidated in terms of tumor biostatistics, number of aberrant crypt foci (ACF), in situ apoptosis assay,changes in morp...
Source: Peptides - Category: Biochemistry Source Type: research
Wastewater treatment plants (WWTPs) are considered hotspots for the environmental dissemination of antimicrobial resistance (AMR) determinants. Vancomycin-Resistant Enterococcus (VRE) are candidates for gauging t...
Source: BMC Microbiology - Category: Microbiology Authors: Tags: Research article Source Type: research
Publication date: Available online 20 December 2019Source: Journal of Hospital InfectionAuthor(s): B. Pilmis, T. Billard-Pomares, M. Martin, C. Clarempuy, C. Lemezo, C. Saint-Marc, N. Bourlon, D. Seytre, E. Carbonnelle, J-R. ZaharSUMMARYBackgroundLittle is known about patient risk factors associated with environmental contamination.AimTo evaluate the rate of environmental contamination and to investigate individual risk factors.MethodsA prospective cohort study was conducted. Each day, five rooms occupied by patients were selected. Five critical surfaces were systematically swabbed twice a day before and after cleaning. Cl...
Source: Journal of Hospital Infection - Category: Infectious Diseases Source Type: research
AbstractPurpose of reviewNeutropenia and its related infections are still a significant challenge in the treatment of patients with onco-hematological diseases, impacting increased mortality and morbidity. In this review, we compiled up-to-date scientific evidence on infection control in neutropenic patients and discussed the potential role of new technologiesRecent findingsTraditional measures such as hand hygiene (HH), patient ’s skincare, central venous catheter care, environment protection, and contact isolation are the cornerstone of infection prevention in neutropenic patients while antibiotic prophylaxis is st...
Source: Current Treatment Options in Infectious Diseases - Category: Infectious Diseases Source Type: research
AbstractPurpose of ReviewEarly diagnosis of infections and immediate initiation of appropriate antimicrobials are crucial in the management of patients before and after organ transplantation. We reviewed the most recent literature and guidelines in this field and organized the current recommendations for healthcare professionals caring for critically ill organ transplant recipients.Recent FindingsThe incidence of multidrug-resistant organisms is increasing. Multidrug-resistant Gram-negative bacteria comprise about 14% of organisms. Vancomycin-resistant enterococci bloodstream infections are also on the rise, as 20.5% of no...
Source: Current Transplantation Reports - Category: Transplant Surgery Source Type: research
ConclusionsC/T may represent a useful option against MDR- and XDR-PA strains responsible of complicated SSTIs in patients affected by impaired renal function.
Source: Infection - Category: Infectious Diseases Source Type: research
Chem. Commun., 2020, Advance Article DOI: 10.1039/C9CC06967D, CommunicationMohini Mohan Konai, Iqbal Pakrudheen, Swagatam Barman, Natalia Sharma, Khatija Tabbasum, Prashant Garg, Jayanta Haldar Cyclam-based antibacterial molecules (CAMs) that display potent activity against both the planktonic and stationary phase of multidrug-resistant Gram-negative bacteria were rationally designed. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - Category: Chemistry Authors: Source Type: research
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