Biofilms of Mycobacterium abscessus complex can be sensitized to antibiotics by disaggregation and oxygenation.
Conclusions: This study explains why current drug susceptibility testing correlates poorly to treatment outcomes. Oxic culturing of planktonic isolates in vitro does not resemble the hypoxic conditions in CF lungs. Biofilm disruption and increasing O2 availability during antibiotic therapy may be new therapeutic strategies for chronic MABSC infection.
PMID: 31740557 [PubMed - as supplied by publisher]
Source: Antimicrobial Agents and Chemotherapy - Category: Microbiology Authors: Kolpen M, Jensen PØ, Qvist T, Kragh KN, Ravnholt C, Fritz BG, Johansen UR, Bjarnsholt T, Høiby N Tags: Antimicrob Agents Chemother Source Type: research
More News: Antibiotic Therapy | Avelox | Azithromycin | Biaxin | Chemotherapy | Cipro | Ciprofloxacin | Clarithromycin | Cystic Fibrosis | Linezolid | Microbiology | Moxifloxacin | Multidrug Resistance | PET Scan | Study | Trimethoprim | Zithromax | Zyvox