Macromolecular approach for targeted radioimmunotherapy in non-Hodgkin's lymphoma.

Macromolecular approach for targeted radioimmunotherapy in non-Hodgkin's lymphoma. Chem Commun (Camb). 2019 Nov 18;: Authors: Hee C, Ho D, Karton A, Nealon G, Kretzmann JA, Norret M, Iyer KS Abstract Polymers are an attractive anchoring platform for the synthesis of radioimmunoconjugates. They enable independent control over the amount of radioisotope loading and antibody attachment, which is pivotal in developing tailorable formulations for personalised medicine. Herein, we report the synthesis of p(HEMA-ran-GMA) for the conjugation of lutetium ions and rituximab as a functional platform for radioimmunotherapy. We demonstrate the suitability of this platform using non-Hodgkin's lymphoma cells. PMID: 31735949 [PubMed - as supplied by publisher]
Source: Chemical Communications - Category: Chemistry Authors: Tags: Chem Commun (Camb) Source Type: research