Antibacterial and osteoinductive biomacromolecules composite electrospun fiber.

In this study, silver nanoparticles (Ag-NPs) were uniformly distributed on the inner of Polylactic acid and Gelatin composite fibers (PLLA and Gel, biological macromolecules) by co-electrospinning for improving anti-infection ability and osseointegration. The optimized experimental conditions for this method were having PLLA/Gel mass ratio of 90:10 and Ag content of 7%. Ag-NPs acted as heterogeneous nucleation sites for promoting the nucleation and growth of calcium phosphorus on the surface of composite fiber. Bone marrow-derived mesenchymal stem cells adhered and proliferated well on the surface of the composite fiber, and the positive fluorescence staining indicated the existence of osteoblasts. Vascular endothelial cells had a good adherence and proliferation on the surface of composite fiber, showing good angiogenic properties. Antibacterial rate of the composite fiber was all over 97% against Monilia albicans, Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa, showing good antibacterial property. A multi-functional biomacromolecules composite fiber was constructed and shown good bioactivity, osteoinductivity, angiogenic and antibacterial properties. PMID: 31739052 [PubMed - as supplied by publisher]
Source: International Journal of Biological Macromolecules - Category: Biochemistry Authors: Tags: Int J Biol Macromol Source Type: research