Salvage Therapy Using Bacillus Calmette-Gu érin Derivatives or Single Agent Chemotherapy

Despite therapy with intravesical Bacillus Calmette-Gu érin, roughly 50% of patients with high-risk non-muscle-invasive bladder cancer will recur. Although cystectomy is the oncologic gold standard in BCG unresponsive disease, salvage intravesical therapies are valuable treatment options that aim to preserve quality of life while decreasing the risk of cancer recurrence and progression. Single-agent intravesical chemotherapy has been a mainstay salvage treatment and foundational to future trials of combination therapy. Treatment with Bacillus Calmette-Guérin derivative therapies has shown promise with response rates comparable with those of sing le agent chemotherapy and may warrant further investigation in the continued climate of Bacillus Calmette-Guérin shortages.
Source: Urologic Clinics of North America - Category: Urology & Nephrology Authors: Source Type: research