$20 million fundraising initiative will support efforts to improve treatment for lung disease

UCLA Health has launched a $20 million fundraising initiative to create a new center for advanced lung disease at theDavid Geffen School of Medicine at UCLA. To date, the initiative has secured $4.37 million for the Lung Health Research Accelerator Fund, including three gifts of $1 million each from Michael and Linda Keston, William Pierpoint, and Jeffrey and Robin Raich, and a total of $1.37 million from nine other donors.The fund will support the work of Dr. John Belperio and Dr. Joseph Lynch III in the medical school ’s division of pulmonary and critical care medicine. Belperio’s research is focused on identifying the causes of and potential treatments for transplant rejection and advanced lung diseases, including chronic obstructive pulmonary disease, emphysema, idiopathic pulmonary fibrosis, sarcoidosis an d interstitial lung disease.Because of the overlap among those conditions, discoveries related to one disease could help lead to advances in understanding and treating the others.“Existing treatments for advanced lung diseases are unimpressive and leave patients with one option — lung transplantation,” said Belperio, who holds the Guitiara Pierpoint Endowed Chair in Interstitial Pulmonary Fibrosis. “Unfortunately, transplantation is not a cure, with only half of lung transplant recipients surviving five years. “Our patients deserve better. We need novel treatments that improve patients’ quality of life and ultimately...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news

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In this study, we searched for soluble SSEA-1+ glycoproteins secreted from deviated cells generated by culturing hiPSCs in cell culture medium containing heat-inactivated supplements. Glycoproteins obtained from cell culture supernatants of SSEA-1+ deviated cells were enriched by an O-glycan binding lectin and blotted with anti-SSEA-1 antibody. A single protein band at>250 kDa specifically detected by anti-SSEA-1 antibody was identified as fibronectin (FN) by LC-MS/MS analysis and immunoprecipitation combined with western blotting, indicating that FN is a carrier protein of SSEA-1. We then constructed a sandwich en...
Source: Biochemical and Biophysical Research communications - Category: Biochemistry Authors: Tags: Biochem Biophys Res Commun Source Type: research
CONCLUSION: Lxrα's anti-atherosclerotic effects in Ldlr-/- mice are not primarily attributable to Lxrα's influence on Arl7 expression. This evidence suggests that Lxrα's effects on plaque inflammation may be more critical to in vivo atherogenesis than its effects on macrophage cholesterol efflux and foam cell development. PMID: 32736671 [PubMed - as supplied by publisher]
Source: Biochemical and Biophysical Research communications - Category: Biochemistry Authors: Tags: Biochem Biophys Res Commun Source Type: research
CONCLUSION: miR-182-5p mimic therapy inhibits the pathogenic Th17 response in EAU mice. miR-182-5p's inhibition of TAF15 negatively regulates Th17 cell development by suppressing STAT3 phosphorylation. As TAF15 shows a positive relationship with Th17 cell markers in uveitis patients, the miR-182-5p/TAF15 axis shows promise as a therapeutic target for uveitis. PMID: 32736708 [PubMed - as supplied by publisher]
Source: Biochemical and Biophysical Research communications - Category: Biochemistry Authors: Tags: Biochem Biophys Res Commun Source Type: research
Publication date: Available online 1 August 2020Source: Hematology/Oncology Clinics of North AmericaAuthor(s): Jordan Gauthier, David G. Maloney
Source: Hematology Oncology Clinics of North America - Category: Hematology Source Type: research
HAIR LOSS is noticeable, even if it's only you who is spotting it. If you're short of some extra cash for an impending hair transplant, what can you do? It's time to nourish the strands you have.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Authors: Ghali MGZ, Stewart R, Ghali GZ, Blitzer W Abstract Facile identification of cardiac allograft vasculopathy (CAV), extensively prevalently identifiable across recipients of cardiac explanted allografts, has proven challenging using non-invasive modalities exclusively. We consequently sought to evaluate diagnostic precision and accuracy of two-dimensional speckle tracking echocardiography (2D-STE) to the end of detecting international society heart &lung transplantation stage III graft vasculopathy (ISHLT-CAV3) in individuals having received cardiac allografts by the meritorious pre-mortem scripted or ve...
Source: Acta Cardiologica - Category: Cardiology Tags: Acta Cardiol Source Type: research
In 2009, CNN's Dr. Sanjay Gupta profiled Connie Culp, a woman who received the first near-total face transplant in the US in 2008. She was injured by a bullet in 2004 when her husband shot her. According to the Cleveland Clinic, Culp has died at the age of 57.
Source: CNN.com - Health - Category: Consumer Health News Source Type: news
Source: Reuters: Health - Category: Consumer Health News Source Type: news
Publication date: October 2020Source: IJC Heart &Vasculature, Volume 30Author(s): R.O. Ohiomoba, Q.R. Youmans, P.W. Akanyirige, A.U. Ezema, A.S. Anderson, A. Bryant, K. Jackson, E. Mandieka, D.T. Pham, Y. Raza, J.D. Rich, C.W. Yancy, I.S. Okwuosa
Source: IJC Heart and Vasculature - Category: Cardiology Source Type: research
Purpose of review This review summarizes recent progress in the diagnosis and management of irritable bowel syndrome, with a focus on dietary and microbiota aspects. Recent findings From a pathophysiological point of view, IBS is a multifactorial condition with both peripheral (transit) as central (visceral hypersensitivity, anxiety, depression) contribution in a cumulative fashion to the symptom pattern and severity. More recently, the focus has shifted to diet and microbiota. The number of dietary options that can be used for IBS and the understanding of determinants of their efficacy is rapidly increasing. Several ...
Source: Current Opinion in Psychiatry - Category: Psychiatry Tags: PSYCHIATRY, MEDICINE AND THE BEHAVIOURAL SCIENCES: Edited by Mohan Isaac and Igor Filipcic Source Type: research
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