Dozens of UCLA scientists rank among world ’s most-cited researchers

The 2019 list of the world ’s most influential scientific researchers includes 47 UCLA scholars.In its annual list, the Web of Science Group, which is a Clarivate Analytics company, names the most highly cited researchers — those whose work was most often referenced by other scientific research papers published from 2008 through 2018 in 21 fields across the sciences and social sciences.“The Highly Cited Researchers 2019 list from the Web of Science Group contributes to the identification of that small fraction of the researcher population that contributes disproportionately to extending the frontiers of knowledge and gaining for society innovations that make the world healthier, richer, more sustainable, and more secure,” according to Web of Science Group.UCLA researchers on the list have affiliations that include the UCLA College, the David Geffen School of Medicine, the Samueli School of Engineering, the Fielding School of Public Health, the California NanoSystems Institute, the Jonsson Comprehensive Cancer Center, and the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research.Current UCLA faculty members and researchers who were named to the list, noted with their primary UCLA research field or fields, are:Matthew Budoff, cardiologyDuilio Cascio, molecular biologyJun Chen, bioengineeringBartosz Chmielowski, hematology and oncologyMichelle Craske, psychology, psychiatry and biobehavioral sciencesXiangfeng Duan, chemistryBruc...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news

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Source: FT.com - Drugs and Healthcare - Category: Pharmaceuticals Source Type: news
Conclusions: CD200 has a great impact in diagnosing B- chronic lymphoproliferative disorders, especially when we want to determine the origin of a CD19, CD5 positive population and distinguish between CLL and MCL. CD 23 is a reliable marker in those cases, but, as we showed, CD23 might have a lower specificity than CD200 for CLL. We added CD200 in our panels in order to diagnose chronic lymphoproliferative disorders, not to replace CD 23, but to improve and save time in our diagnostic process. The high expression of CD200 in CLL and HCL could open the option for new- targeted therapy (anti-CD200). PMID: 31803290 [PubMed]
Source: Journal of Medicine and Life - Category: General Medicine Tags: J Med Life Source Type: research
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
In conclusion, CTD-2357A8.3 may be considered a promising diagnosis biomarker or a therapeutic target for the treatment of HNSCC. PMID: 31807160 [PubMed]
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
This study aimed to provide mechanistic insights into mitophagy pathway associated with papillomavirus infection in urothelial cells of cattle. The elimination of mitochondria via autophagy, termed mitophagy, is an evolutionarily conserved mechanism for mitochondrial quality control and homeostasis. PINK1/parkin-mediated mitophagy, a ubiquitin-dependent selective autophagy of dysfunctional mitochondria, has been described here, for the first time, in urothelial cells from 25 bladder cancers in cattle infected by bovine papillomavirus (BPV). The expression of BPV-2 and BPV-13 E5 oncoprotein was detected by RT-PCR. Abnormal ...
Source: Comparative Immunology, Microbiology and Infectious Diseases - Category: Infectious Diseases Source Type: research
Publication date: Available online 7 December 2019Source: The Lancet HaematologyAuthor(s): Kris M Mahadeo, Rajinder Bajwa, Hisham Abdel-Azim, Leslie E Lehmann, Christine Duncan, Nicole Zantek, Jennifer Vittorio, Joseph Angelo, Jennifer McArthur, Keri Schadler, Sherwin Chan, Priti Tewari, Sajad Khazal, Jeffery J Auletta, Sung Won Choi, Basirat Shoberu, Krzysztof Kalwak, Avis Harden, Partow Kebriaei, Jun-ichi AbeSummarySinusoidal obstructive syndrome, also known as hepatic veno-occlusive disease, is a potentially life-threatening complication that occurs in children undergoing haemopoietic stem-cell transplantation (HSCT). D...
Source: The Lancet Haematology - Category: Hematology Source Type: research
CONCLUSION: BCSCs involved in cancer pathogenesis, therapy resistance and cancer recurrence. Thus, it is suggested that a multi-dimensional therapeutic approach by targeting surface markers and aberrantly activated signaling pathways of BCSCs alone or in combination with each other could really be worthwhile in the treatment of breast cancer. PMID: 31808385 [PubMed - in process]
Source: Current Stem Cell Research and Therapy - Category: Stem Cells Authors: Tags: Curr Stem Cell Res Ther Source Type: research
Publication date: Available online 22 October 2019Source: Seminars in Cancer BiologyAuthor(s): Tamara T. Lah, Metka Novak, Barbara BreznikAbstractBrain, the major organ of the central nervous system controls and processes most of body activities. Therefore, the most aggressive brain tumor – glioblastoma and metastases from other organs to the brain are lethal leaving the patients with very short time of survival. The brain tissue landscape is very different from any other tissues and the specific microenvironment, comprising stem cells niches and blood-brain barrier, significantly influences the low rate of glioblast...
Source: Seminars in Cancer Biology - Category: Cancer & Oncology Source Type: research
Authors: Malhotra H, Radich J, Garcia-Gonzalez P Abstract Subsequent to the development and global availability of BCR/ABL-targeted tyrosine kinase inhibitors (TKIs), the prognosis of patients with chronic myeloid leukemia (CML), at least those in the chronic phase, has markedly improved, and in the developed world, the average lifespan of these patients is now close to that of age- and sex-matched subjects without the disease. However, the situation in low- and middle-income countries (LMICs) may not be so rosy. Many important differences in hematological cancers, including CML, have been highlighted in various pu...
Source: Hematology ASH Education Program - Category: Hematology Tags: Hematology Am Soc Hematol Educ Program Source Type: research
Authors: Severyn CJ, Brewster R, Andermann TM Abstract Growing evidence suggests that human microbiota likely influence diverse processes including hematopoiesis, chemotherapy metabolism, and efficacy, as well as overall survival in patients with hematologic malignancies and other cancers. Both host genetic susceptibility and host-microbiota interactions may impact cancer risk and response to treatment; however, microbiota have the potential to be uniquely modifiable and accessible targets for treatment. Here, we focus on strategies to modify microbiota composition and function in patients with cancer. First, we ev...
Source: Hematology ASH Education Program - Category: Hematology Tags: Hematology Am Soc Hematol Educ Program Source Type: research
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