Inflammation in deep vein thrombosis: a therapeutic target?

Inflammation in deep vein thrombosis: a therapeutic target?
Hematology. 2019 Dec;24(1):742-750
Authors: Borgel D, Bianchini E, Lasne D, Pascreau T, Saller F
Abstract
Deep vein thrombosis is a common disease associated with a variety of complications including post-thrombotic syndrome as a late complication. It is now clear that in addition to classical deep vein thrombosis triggers such as blood flow disturbance, hypercoagulability, and vessel wall changes, inflammation has a key role in the pathophysiology of deep vein thrombosis, and there is a close relationship between inflammation and coagulation. As attested by changes in several plasma biomarkers, inflammation may have a significant role in the development of post-thrombotic syndrome. Here, we review the link between inflammation and deep vein thrombosis and thus the potential value of anti-inflammatory and/or anticoagulant drugs in the treatment of deep vein thrombosis and the prevention of post-thrombotic syndrome.
PMID: 31736432 [PubMed - in process]

Source: Hematology - November 20, 2019 Category: Hematology Tags: Hematology Source Type: research