A novel AIFM1 missense mutation in a Japanese patient with ataxic sensory neuronopathy and hearing impairment
Apoptosis-Inducing Factor Mitochondria-associated-1 gene (AIFM1) encodes a mitochondrial flavin adenine dinucleotide-dependent nicotinamide oxidoreductase, which has a biological role in oxidative phosphorylation (OXPHOS) and in apoptosis pathway [1]. AIFM1 mutations have been reported to be associated with various neurological diseases, including Cowchock syndrome (OMIM 310490) [2], X-linked recessive Charcot-Marie-Tooth disease-4 (CMTX4), X-linked deafness-5 (DFNX5; OMIM 300614) [3], and hypomyelinating leukodystrophy and spondylometaphyseal dysplasia (H-SMD) [4].
Source: Journal of the Neurological Sciences - Category: Neurology Authors: Toshitaka Kawarai, Hiroki Yamazaki, Kei Yamakami, Ai Tsukamoto-Miyashiro, Mizuki Kodama, Roberto Rumore, Carlo Caltagirone, Ichizo Nishino, Antonio Orlacchio Tags: Letter to the Editor Source Type: research
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