Polyphenolic extract (PE) from olive oil exerts a potent immunomodulatory effect and prevents graft-versus-host disease in a mouse model
Graft-versus-host disease (GVHD) is one of the most common complications after allogeneic hematopoietic stem-cell transplantation (allo-HSCT) [1]. It remains a significant cause of treatment failure, resulting in mortality> 20% and morbidity> 50% of transplant recipients [2]. Acute GVHD (aGVHD) is mediated by alloreactive immunocompetent donor T cells as well as the delivery of proinflammatory cytokines which induce damage in target organs such as skin, liver or gastrointestinal tract. [3 –4]
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Isabel Alvarez-Laderas, Teresa L. Ramos, Mayte Medrano, Roc ío Caracuel-García, María Victoria Barbado, Marina Sánchez-Hidalgo, Rosario Zamora, Catalina Alarcón-de-la-Lastra, Francisco J. Hidalgo, José Ignacio Piruat, Teresa Caballero-Velázquez, Jo Source Type: research
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