Polyphenolic extract (PE) from olive oil exerts a potent immunomodulatory effect and prevents graft-versus-host disease in a mouse model

Graft-versus-host disease (GVHD) is one of the most common complications after allogeneic hematopoietic stem-cell transplantation (allo-HSCT) [1]. It remains a significant cause of treatment failure, resulting in mortality> 20% and morbidity> 50% of transplant recipients [2]. Acute GVHD (aGVHD) is mediated by alloreactive immunocompetent donor T cells as well as the delivery of proinflammatory cytokines which induce damage in target organs such as skin, liver or gastrointestinal tract. [3 –4]
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Source Type: research