Mangiferin glycethosomes as a new potential adjuvant for the treatment of psoriasis

Publication date: Available online 18 November 2019Source: International Journal of PharmaceuticsAuthor(s): M. Pleguezuelos-Villa, Octavio Diez-Sales, Maria Letizia Manca, Maria Manconi, Amparo Ruiz Sauri, Elvira Escribano-Ferrer, Amparo NácherAbstractMangiferin, a natural compound isolated from Mangifera indica L, was incorporated in glycerosomes, ethosomes and alternatively in glycerol-ethanol phospholipid vesicles (glycethosomes). Actually, only glycethosomes were able to stably incorporate the mangiferin that was loaded at increasing concentrations (2, 4, 6, 8 mg/mL). The morphology, size distribution, rheological properties, surface charge and entrapment efficiency of prepared vesicles were deeply measured. All vesicles were mainly spherical, oligolamellar, small in size (∼145 nm) and negatively charged (∼-40 mV), as confirmed by cryo-TEM observation and dynamic laser light scattering measurements. The higher concentration of mangiferin (8 mg/mL) allowed an increase of vesicle mean diameter up to ∼288 nm. The entrapment efficiency was inversely proportional to the amount of loaded mangiferin.In vitro studies performed by using human abdominal skin, underlined that, the dose-dependent ability of vesicles to promote mangiferin retention in epidermis. In addition, glycethosomes were highly biocompatible and showed a strong ability to protect in vitro the fibroblasts against damages induced by hydrogen peroxide. In vivo results underlined the superior ability of mangi...
Source: International Journal of Pharmaceutics - Category: Drugs & Pharmacology Source Type: research