Transcriptome mining and B cell depletion support a role for B cells in psoriasis pathophysiology

Increasing evidence suggests that certain subpopulations of B cells can have regulatory functions. Herein, we report immunohistochemical and clinical evidence of psoriasis following B cell depletion with rituximab, administered as therapy for pemphigus vulgaris. We also mine RNA-Seq datasets to help elucidate a role for B cells in psoriasis pathophysiology, an understudied but potentially important area of further investigation.

Source: Journal of Dermatological Science - November 18, 2019 Category: Dermatology Authors: A. Toussi, A. Merleev, V.R. Barton, S.T. Le, A. Marusina, G. Luxardi, J. Kirma, X. Xing, I.E. Adamopoulos, MA Fung, S.P Raychaudhuri, M Shimoda, J.E. Gudjonsson, E. Maverakis Tags: Letter to the Editor Source Type: research