Age-Related Dopaminergic Innervation Augments T Helper 2-Type Allergic Inflammation in the Postnatal Lung

Children are more prone to developing allergic asthma than adults. Wang et  al. find that sympathetic nerves undergo a dopaminergic-to-adrenergic transition during post-natal development of the lung. Dopamine signaling in CD4+ T cells promotes a Th2 phenotype, which makes young mice more susceptible to allergy. These findings provide an age-related mechanism underlying t he susceptibility of the young to allergic inflammation.

Source: Immunity - November 18, 2019 Category: Allergy & Immunology Authors: Wei Wang, Jonathan A. Cohen, Antonia Wallrapp, Kenneth G. Trieu, Juliana Barrios, Fengzhi Shao, Nandini Krishnamoorthy, Vijay K. Kuchroo, Matthew R. Jones, Alan Fine, Yan Bai, Xingbin Ai Tags: Article Source Type: research