Age-Related Dopaminergic Innervation Augments T Helper 2-Type Allergic Inflammation in the Postnatal Lung
Children are more prone to developing allergic asthma than adults. Wang et al. find that sympathetic nerves undergo a dopaminergic-to-adrenergic transition during post-natal development of the lung. Dopamine signaling in CD4+ T cells promotes a Th2 phenotype, which makes young mice more susceptible to allergy. These findings provide an age-related mechanism underlying t he susceptibility of the young to allergic inflammation.
Source: Immunity - Category: Allergy & Immunology Authors: Wei Wang, Jonathan A. Cohen, Antonia Wallrapp, Kenneth G. Trieu, Juliana Barrios, Fengzhi Shao, Nandini Krishnamoorthy, Vijay K. Kuchroo, Matthew R. Jones, Alan Fine, Yan Bai, Xingbin Ai Tags: Article Source Type: research
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