Large-Scale HLA Tetramer Tracking of T Cells during Dengue Infection Reveals Broad Acute Activation and Differentiation into Two Memory Cell Fates

Understanding T  cell responses to dengue infection is important for developing effective vaccines. Chng et al. used high-dimensional CyTOF profiling and peptide-HLA tetramer screening to track dengue-specific T cell activation and differentiation into memory cells in naturally infected patients. They found that dengue infection causes broad immune cell activation and that dengue-specific T cells differentiate into two major cell fates.

Source: Immunity - November 18, 2019 Category: Allergy & Immunology Authors: Melissa Hui Yen Chng, Mei Qiu Lim, Angeline Rouers, Etienne Becht, Bernett Lee, Paul A. MacAry, David Chien Lye, Yee Sin Leo, Jinmiao Chen, Katja Fink, Laura Rivino, Evan W. Newell Tags: Resource Source Type: research