Lipid Metabolism Alterations in a Rat Model of Chronic and Intergenerational Exposure to Arsenic.

Lipid Metabolism Alterations in a Rat Model of Chronic and Intergenerational Exposure to Arsenic. Biomed Res Int. 2019;2019:4978018 Authors: Rivas-Santiago C, González-Curiel I, Zarazua S, Murgu M, Ruiz Cardona A, Lazalde B, Lara-Ramírez EE, Vázquez E, Castañeda-Delgado JE, Rivas-Santiago B, Lopez JA, Cervantes-Villagrana AR, López-Hernández Y Abstract Chronic exposure to arsenic (As), whether directly through the consumption of contaminated drinking water or indirectly through the daily intake of As-contaminated food, is a health threat for more than 150 million people worldwide. Epidemiological studies found an association between chronic consumption of As and several pathologies, the most common being cancer-related disorders. However, As consumption has also been associated with metabolic disorders that could lead to diverse pathologies, such as type 2 diabetes mellitus, nonalcoholic fatty liver disease, and obesity. Here, we used ultra-performance liquid chromatography (UPLC) coupled to electrospray ionization/quadrupole time-of-flight mass spectrometry (ESI-QToF) to assess the effect of chronic intergenerational As exposure on the lipid metabolism profiles of serum from 4-month-old Wistar rats exposed to As prenatally and also during early life in drinking water (3 ppm). Significant differences in the levels of certain identified lysophospholipids, phosphatidylcholines, and triglycerides were found b...
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research

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