Clitoria ternatea L. petal bioactive compounds display antioxidant, antihemolytic and antihypertensive effects, inhibit α-amylase and α-glucosidase activities and reduce human LDL cholesterol and DNA induced oxidation

Publication date: February 2020Source: Food Research International, Volume 128Author(s): Graziela Bragueto Escher, Mariza Boscacci Marques, Mariana Araújo Vieira do Carmo, Luciana Azevedo, Marianna Miranda Furtado, Anderson S. Sant'Ana, Marcia Cristina da Silva, Maria Inês Genovese, Mingchun Wen, Liang Zhang, Won Young Oh, Fereidoon Shahidi, Neiva Deliberali Rosso, Daniel GranatoAbstractThe purpose of this study was to use a statistical approach to optimise the experimental conditions regarding the extraction of bioactive compounds, and to analyse the in vitro functional properties of crude lyophilized extracts (CLE) and partially purified (PPE) extracts of Clitoria ternatea petals. The results showed that the factors of temperature and time influenced the extraction of phenolic compounds, antioxidant activity and the physicochemical parameters. Simultaneous optimisation showed that the same levels of bioactive compounds were extracted when using temperatures from 11.7 to 68.3 °C and times from 8.47 to 51.12 min. Principal component analysis revealed the experimental conditions that provided the extraction producing the highest level of phenolic content (40 °C/30 min). The CLE showed antimicrobial activity; protective effect against hemolysis of erythrocytes; inhibition of α-amylase, α-glucosidase and angiotensin-I-converting (ACE-I) enzymes; and inhibition of lipid peroxidation. The CLE and PPE demonstrated oxygen radical absorption c...
Source: Food Research International - Category: Food Science Source Type: research

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