Clinico-microbiological analysis of toxigenic clostridium difficile from hospitalised patients in a tertiary care hospital, Mangalore, Karnataka, India

Conclusion: The presence of toxigenic C. difficile in our locality is a matter of concern. Constant supervision, appropriate treatment and preventive measures are crucial in controlling C. difficile infection.
Source: Indian Journal of Medical Microbiology - Category: Microbiology Authors: Source Type: research

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Blessing O. Anonye1, Jack Hassall2, Jamie Patient3, Usanee Detamornrat3, Afnan M. Aladdad3, Stephanie Schüller4,5, Felicity R. A. J. Rose3 and Meera Unnikrishnan1* 1Microbiology and Infection Unit, Division of Biomedical Sciences, Warwick Medical School, University of Warwick, Coventry, United Kingdom 2Warwick Integrative Synthetic Biology Centre, School of Life Sciences, University of Warwick, Coventry, United Kingdom 3Division of Regenerative Medicine and Cellular Therapies, School of Pharmacy, Centre for Biomolecular Sciences, University of Nottingham, Nottingham, United Kingdom 4Norwich Medical School, F...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
LITFL • Life in the Fast Lane Medical Blog LITFL • Life in the Fast Lane Medical Blog - Emergency medicine and critical care medical education blog aka Tropical Travel Trouble 004 A medical student who has just returned from their elective in Nepal presents with 1 week of bloody diarrhoea. He has been in the lowlands and stayed with a family in the local village he was helping at. It started three days before he left and he decided to get home on the plane in the hope it would settle. He is now opening his bowels 10x a day with associated cramps, fevers and has started feeling dizzy. Questions: Q1. What is dyse...
Source: Life in the Fast Lane - Category: Emergency Medicine Authors: Tags: Clinical Cases Tropical Medicine amoebic dysentery bacillary dysentery e.histolytica entamoeba histolytica shigellosis Source Type: blogs
Conclusion The initiation of contact precaution has to be assessed for 4.3% of all emergency department patients; 19% of the patients who had a sample tested had highly contagious gastroenteritis and required strict contact precautions. Further studies for developing tools to determine whom to isolate are needed.
Source: Journal of Hospital Infection - Category: Infectious Diseases Source Type: research
ConclusionsThe results suggest that community prescribed ASMs were associated with increased rates of C. difficile and Campylobacter positive gastroenteritis in both the community and hospital settings.
Source: British Journal of Clinical Pharmacology - Category: Drugs & Pharmacology Authors: Tags: DRUG SAFETY Source Type: research
ConclusionsThe results suggest that community prescribed ASMs were associated with increased rates of C. difficile and Campylobacter positive gastroenteritis in both the community and hospital settings.
Source: British Journal of Clinical Pharmacology - Category: Drugs & Pharmacology Authors: Tags: DRUG SAFETY Source Type: research
Conclusions Oral vancomycin induces drastic and consistent changes in the human intestinal microbiota. Upon vancomycin cessation, the microbiota recovery rate varied considerably among subjects, which could influence, as validated in mice, the level of susceptibility to pathogen intestinal colonization. Our results demonstrate the negative long-term effects of vancomycin, which should be considered as a fundamental aspect of the cost–benefit equation for antibiotic prescription.
Source: Journal of Antimicrobial Chemotherapy - Category: Microbiology Authors: Tags: Original research Source Type: research
Publication date: Available online 17 September 2016 Source:Veterinary Microbiology Author(s): Mirjam Duijvestijn, Lapo Mughini-Gras, Nancy Schuurman, Wim Schijf, Jaap Wagenaar, Herman Egberink Laboratory confirmation of the causative agent(s) of diarrhoea in puppies may allow for appropriate treatment. The presence of potential pathogens however, does not prove a causal relationship with diarrhoea. The aim of this study was to identify specific enteropathogens in ≤12 month old puppies with and without acute diarrhoea and to assess their associations with clinical signs, putative risk factors and pathogen co-occurrence...
Source: Veterinary Microbiology - Category: Veterinary Research Source Type: research
Publication date: Available online 23 July 2016 Source:The Lancet Author(s): Amit C Nathwani, James F Down, John Goldstone, James Yassin, Paul I Dargan, Andres Virchis, Nick Gent, David Lloyd, John D Harrison Background Polonium-210 (210Po) gained widespread notoriety after the poisoning and subsequent death of Mr Alexander Litvinenko in London, UK, in 2006. Exposure to 210Po resulted initially in a clinical course that was indistinguishable from infection or exposure to chemical toxins, such as thallium. Methods A 43-year-old man presented to his local hospital with acute abdominal pain, diarrhoea, and vomitin...
Source: The Lancet - Category: Journals (General) Source Type: research
Conclusion In areas with limited personnel and resources, regular investigation of the point prevalence of HCAIs can be performed in lieu of comprehensive monitoring to elucidate risk factors and disease burdens of HCAIs.
Source: Journal of Hospital Infection - Category: Infectious Diseases Source Type: research
In conclusion, the treatment of acute diarrhoea is still primarily supportive. General empirical antibiotic therapy for acute diarrhoea is not evidence-based. PMID: 26641310 [PubMed - in process]
Source: Expert Review of Anti-Infective Therapy - Category: Infectious Diseases Tags: Expert Rev Anti Infect Ther Source Type: research
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