Liquid formulation of ifosfamide increased risk of encephalopathy: A case-control study in a pediatric population.

CONCLUSIONS: Observed difference does not seem to be related to the pathology treated, the doses used, the co-medications, a meningeal localization and/or an irradiation of the central nervous system. This study confirms data from spontaneous reports that led to the precautionary measure for the liquid formulation. Even if the risk of encephalopathy seems reduced, our study suggests the persistence of a residual risk of encephalopathy associated with liquid formulation compared to the lyophilized powder. PMID: 31732241 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/31732241?dopt=Abstract

Source: Therapie - October 27, 2019 Category: Psychiatry & Psychology Authors: Hillaire-Buys D, Mousset M, Allouchery M, Azzouz B, Babin M, Bellet F, Béné J, Default A, Durrieu G, Géniaux H, Grandvuillemin A, Gras-Champel V, Jantzem H, Lambert A, Lepelley M, Massy N, Petitpain N, Rocher F, Sanchez-Pena P, Sassier M, Simon C, Triq Tags: Therapie Source Type: research