Preventive effects of l-glutamine on gestational fructose-induced cardiac hypertrophy: involvement of pyruvate dehydrogenase kinase-4

Applied Physiology, Nutrition, and Metabolism, e-First Articles. Gestational fructose exposure has detrimental health consequences on both the maternal and fetus or offspring in the early or later life, contributing to epidemic rise in cardiometabolic syndrome including cardiac events. l-Glutamine has been shown to mitigate cardiac metabolic stress. However, the effect of l-glutamine on cardiac hypertrophy induced by gestational fructose exposure is not known. We therefore hypothesized that l-glutamine would prevent gestational fructose-induced cardiac hypertrophy, possibly by suppression of pyruvate dehydrogenase kinase-4 (PDK-4). Pregnant Wistar rats were allotted into the control, l-glutamine, gestational fructose exposure, and gestational fructose exposure plus l-glutamine groups (6 rats in each group). The groups received distilled water (vehicle, per os), 1 g/kg body weight l-glutamine (per os), 10% fructose (w/v) and 10% fructose (w/v) plus 1 g/kg l-glutamine (per os), respectively, daily for 19 days. Data from this study showed that gestational fructose-enriched drink caused cardiac hypertrophy with correspondent body weight gain, glucose dysregulation, increased cardiac PDK-4, triglyceride, glycogen, lactate, and uric acid production. On the other hand, defective glutathione-dependent antioxidant barrier was also observed in pregnant rats taking fructose-enriched drink. However, the gestational fructose-induced cardiac hypertrophy and its correlates were attenuated b...
Source: Applied Physiology, Nutrition, and Metabolism - Category: Physiology Authors: Source Type: research

Related Links:

By SAURABH JHA, MD Slumdog TB No one knows who gave Rahul Roy tuberculosis. Roy’s charmed life as a successful trader involved traveling in his Mercedes C class between his apartment on the plush Nepean Sea Road in South Mumbai and offices in Bombay Stock Exchange. He cared little for Mumbai’s weather. He seldom rolled down his car windows – his ambient atmosphere, optimized for his comfort, rarely changed. Historically TB, or “consumption” as it was known, was a Bohemian malady; the chronic suffering produced a rhapsody which produced fine art. TB was fashionable in Victorian Britain...
Source: The Health Care Blog - Category: Consumer Health News Authors: Tags: Artificial Intelligence Health Tech Saurabh Jha TB tuberculosis Source Type: blogs
AbstractVitamin A (VA) has pleiotropic effects on the immune system and is critical for mucosal immune function and intestinal lymphocyte trafficking. We hypothesized that oral VA supplementation of porcine epidemic diarrhea virus (PEDV)-infected pregnant gilts would enhance the gut-mammary gland-secretory IgA axis to boost lactogenic immunity and passive protection of nursing piglets against PEDV challenge. Gilts received daily oral retinyl acetate (30  000 IU) starting at gestation day 76 throughout lactation. At 3–4 weeks pre-partum, VA-supplemented (PEDV + VA) and non-supplemented (PE...
Source: Veterinary Research - Category: Veterinary Research Source Type: research
Credit: S. Oka/WHO By Ifeanyi NsoforABUJA, Nov 27 2019 (IPS) Dr. Wouter, a Dutch doctor who helped perform surgeries and train colleagues in surgical skills in underserved areas of Sierra Leone died of Lassa Fever. He was infected as a result of performing a Caesarean section on an infected pregnant woman.  This was a very painful and avoidable death. I mourn with his family and the Dutch people over this loss. No health worker should die while trying to save lives. Sadly, every year 5,000 West Africans die from Lassa fever. Lassa fever is a viral disease of inequity and disproportionately affects ...
Source: IPS Inter Press Service - Health - Category: International Medicine & Public Health Authors: Tags: Africa Headlines Health Poverty & SDGs TerraViva United Nations Lassa Fever Source Type: news
(JAMA. 2019;321(4):352–353) Understanding the context of drug use is important to fully understanding the opioid epidemic, and with it, neonatal abstinence syndrome (NAS). NAS is associated with opioid exposure and manifests with hyperirritability at birth, difficulty feeding, and respiratory problems. NAS occurs alongside prescription as well as nonprescription opioid use, including buprenorphine and methadone prescribed to pregnant women for the treatment of opioid addiction. New insights on the structural, social, and community factors that influence neonatal outcomes were described in a recent report by Patrick ...
Source: Obstetric Anesthesia Digest - Category: Anesthesiology Tags: Epidemiologic Reports Surveys Source Type: research
CONCLUSIONS: Early placentomegaly may represent the first sign of trans-placental contamination and should lead to an enhanced follow-up of these pregnancies. This article is protected by copyright. All rights reserved. PMID: 31773804 [PubMed - as supplied by publisher]
Source: The Ultrasound Review of Obstetrics and Gynecology - Category: Radiology Authors: Tags: Ultrasound Obstet Gynecol Source Type: research
AbstractPurpose of ReviewAs research efforts have advanced to understand the pathophysiology of viral hemorrhagic fevers (VHF) and other epidemic viral infections and develop medical countermeasures such as vaccines, pregnant women have remained an underexamined subgroup. To better understand the implications of future outbreaks of VHF for pregnant women amidst an evolving vaccine landscape, we examine three pathogens —yellow fever, Ebola, and Lassa fever—each with different levels of evidence and understanding of disease in pregnancy and at varying stages of vaccine development.Recent FindingsThere are very li...
Source: Current Tropical Medicine Reports - Category: Tropical Medicine Source Type: research
AbstractPurpose of ReviewEbola virus infection has one of the highest overall case fatality rates of any viral disease. It has historically had an especially high case mortality rate among pregnant women and infants —greater than 90% for pregnant women in some outbreaks and close to 100 % in fetuses and newborns. The Merck recombinant vaccine against Ebola virus, termed rVSV-ZEBOV, underwent clinical trials during the 2013–2015 West Africa Ebola epidemic where it was found to be 100% efficacious. It was sub sequently used during the 2018 DRC Équateur outbreak and in the 2018 DRC Kivu Ebola which is still...
Source: Current Tropical Medicine Reports - Category: Tropical Medicine Source Type: research
Conclusions: A higher seroprevalence of HEV as compared to HAV together with a co-infection rate of 2.07% mandates screening for HEV in all suspected cases of acute hepatitis, particularly pregnant women in whom the outcomes of HEV infection are poor. Health and civic authorities should make necessary efforts to counter epidemic or outbreak situations, thus reducing morbidity, mortality and economic burden.
Source: Indian Journal of Medical Microbiology - Category: Microbiology Authors: Source Type: research
This article analyzes current issues related to maternal vaccination with a focus on emerging and epidemic viral infections and human rights.Recent FindingsHistorically, pregnant women have not been considered in the development of vaccines and have been excluded from participating in clinical trials and vaccination campaigns. Because of risk for injury and death of mothers and fetuses/infants during infectious disease outbreaks, it is important to consider their rights to receive any potential form of prevention or therapy available to non-pregnant individuals in order to enhance their well-being.SummaryIt is unacceptable...
Source: Current Tropical Medicine Reports - Category: Tropical Medicine Source Type: research
Half of US states now have policies in place that consider opioid use in pregnancy a crime in an effort to stem the epidemic, but a RAND corporation study suggests that these polices may backfire.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
More News: Antidoxidants | Cardiology | Epidemics | Epidemiology | Heart | Legislation | Nutrition | Physiology | Pregnancy | Study